Recreational physical activity can significantly improve endometrial cancer survival and prognosis

A prospective cohort study by Friedenreich of the Alberta Cancer Control Center in Canada and others shows that recreational physical activity, especially after diagnosis, can improve the survival of endometrial cancer patients.
（J Clin Oncol. doi:10.1200/JCO.20.01336）。
The purpose of this study was to assess the association between physical activity and survival of endometrial cancer survivors before and after diagnosis by the range, intensity, degree (metabolic equivalent of MET-time/week/year) and changes from pre-diagnosis to post-diagnosis.
The prospective cohort study, conducted in Alberta, Canada, looked at 425 patients who were histologically diagnosed with immersive endometrial cancer between 2002 and 2006 and followed up until 2019.
The Total Lifetime Physical Activity Questionnaire, conducted by the interviewers, records physical activity before diagnosis (4.4 months after diagnosis) and after diagnosis (median 3.4 years after diagnosis).
after correcting age, station, grading, treatment, body mass index, menophanism, hormone supplementation treatment use, cancer family history, and congerging disorders, the Cox proportional risk model was used to assess the correlation between physical activity and total and disease-free survival.
14.5 years after the mid-level follow-up, 60 deaths (including 18 deaths from endometrial cancer) and 80 disease-free survival events occurred.
more recreational physical activity before diagnosis and improved disease-free survival were statistically significantly related. ≤ 8 MET- hours / weeks / years; HR s 0.54, 95% CI 0.30 to 0.96, P trend s 0.04), but not in terms of total lifetime (HR s 0.56, 95% CI0.29 to 1.07, P trend s 0.06).
more recreational physical activity after diagnosis (-gt;13 MET-hours / weeks / years vs. ≤ 5MET-hours / weeks / years) and improvements in disease-free survival (HR=0.33,95% CI 0.17 There is a strong correlation between the P trend of 0.64, the P trend of 0.001, and the improvement of total lifetime (HR, 0.33, 95% CI0.15 to 0.75, P trend, 0.007).
compared to those who maintained low levels of exercise, participants who maintained high levels of recreational physical activity from pre-diagnosis to post-diagnosis also improved their disease-free survival (HR=0.35,95% CI 0.18-0.69) and total survival (HR=0.43,95% CI 0.20-0.94).
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