Recently, scientists have made new achievements in the field of anxiety research!

In this paper, the editor sorts out the new achievements that scientists have made in the field of anxiety research recently, to learn with you! Photo source: ETI Ben Simon, et al NAT hum behav (2019) doi: 10.1038/s41562-0 19-0754-8 [1] insomnia may increase anxiety level by 30% the next day! Deep sleep can significantly reduce the level of anxiety! Doi: 10.1038/s41562-019-0754-8 recently, an international magazine named "excessive and In the Research Report of "undersleep", scientists from the University of California found that insomnia may increase the anxiety level of the body by 30% the next day; the researchers said that adequate and high-quality sleep can keep people calm and reduce the stress level of the body According to data from the American Association of anxiety and depression, anxiety disorder is the most common mental health problem in the American population About 40 million people (18% of the American population) suffer from anxiety disorder every year According to the researchers, lack of sleep can amplify the anxiety level of the body in a dose-response way Chronic sleep deficiency and acute complete sleep deficiency often significantly increase the anxiety level of healthy individuals Further evidence of the influence of sleep deficiency on anxiety is often from clinical scientific research Sleep disorder is a common symptom of anxiety In addition, sleep disorder is recognized as a common symptom of anxiety Obstruction is also directly related to the occurrence and progress of anxiety disorders The evidence of its relevance lies in that sleep disorders usually exist in the whole axis of major anxiety disorders, including post-traumatic stress disorder (PTSD), generalized anxiety disorder, panic disorder and social anxiety disorder 【2】 Cell Rep: a new type of brain cell regulates anxiety response doi: 10.1016/j.celrep.2019.09.045 according to the data of the National Institute of mental health, one third of people will feel "weak anxiety", which will affect their normal life Women are also more likely to develop anxiety disorders However, the causes of anxiety and other anxiety related diseases (such as obsessive-compulsive disorder) are still unclear In a new study, scientists at the University of Utah found a new special brain cell subpopulation, called Hoxb8 microglia, and linked it to obsessive-compulsive disorder and anxiety disorder Studies have shown that mice with Hoxb8 microglial defects exhibit excessive "grooming" behavior The symptoms are similar to the behavior of people with obsessive-compulsive disorder, which causes them to comb their hair excessively Their experiments show that Hoxb8 and microglia can prevent the above-mentioned obsessive-compulsive behaviors in mice In addition, they found that oestrogen also triggers more obsessive-compulsive behavior and causes additional anxiety 【3】 J funct foods: why do you always drink Matcha? It may be to relieve anxiety! Doi: 10.1016/j.jff.2019.05.046 many countries have tea culture, Japanese Matcha is more and more popular in the world In Japan, Matcha has a long medicinal history It has been suspected that it has various beneficial effects on health, but there is relatively little scientific evidence to support this claim Now, a team of Japanese researchers at Kumamoto University found that eating Matcha powder or extract reduced anxiety in mice Its sedative effect seems to be due to the activation of dopamine D1 receptor and serotonin 5-HT1A receptor, both of which are closely related to anxiety behavior Matcha is a fine powder made from the new leaves of Chinese tea trees grown in the shade (90% shade) Tea (and food seasoning) is very popular all over the world In Japan, the historical medicinal value of Matcha includes helping people relax, preventing obesity and treating skin diseases Therefore, researchers try to determine its various beneficial effects 【4】 Jneurosci: metformin is the magic drug again! Can alleviate anxiety! Doi: 10.1523/junirosci.2904-18.2019 according to a study published in junirosci, the antidiabetic drug metformin reduces anxiety like behavior in male mice by increasing the use of serotonin in the brain These findings may be useful for the treatment of metabolic disorders and mental disorders Diabetic patients have a higher risk of depression and other emotional disorders Although the underlying mechanism between insulin resistance (a precursor to diabetes) and depression is unclear, studies have shown that neurotransmitter serotonin may be the culprit In mice fed a high-fat diet, insulin sensitizing drug metformin lowered amino acid levels, which disrupted tryptophan's entry into the brain, limiting its conversion to serotonin, the researchers said The drug has an antidepressant effect and improves neural transmission in the hippocampus 【5】 Nat hum behavior: anxiety makes people escape danger faster doi: 10.1038/s41562-019-0595-5 fear and anxiety are all responses to danger, but the response time is different When some threats are imminent, they will feel fear, such as the tiger coming at you When you have time to think about threats, you get anxiety: for example, when you see a tiger running in the distance, you need to choose to escape or hide According to a recent study published in the journal Nature human behavior, the authors showed for the first time how anxious people's brains respond to attack threats of fast (based on fear) and slow (based on anxiety) The results show that most people respond to the rapid threat in the same way, that is, to run away from him But when it comes to the threat of slowness, a person's level of anxiety can have an impact on the response: the more anxious they are, the sooner they will escape the danger Photo source: cc0 public domain [6] cell metal: eliminate the "zombie" cells in the brain or make obese people no longer anxious Doi: 10.1016/j.cmet.2018.12.008 recently, an international journal Cell In the Research Report on metabolism, scientists from Mayo Clinic and other institutions found that obesity may increase the level of aging cells in the brain of mice, thus inducing the occurrence of anxiety disorders in mice When the aging cells are removed by using sensitive drugs, the anxiety behavior of mice will slow down Aging cells are like zombies This kind of semi dormant cells will stay in specific areas of the body and damage the health of the body Research results show that aging cells can induce many aging related diseases, such as osteoporosis and diabetes , even myasthenia, etc.; we found that obesity may also be directly related to the increase of anxiety level and other emotional problems, but the researchers have not clarified the specific relationship 【7】 Nat commun: special cells in the hippocampus may help control anxiety and risk-taking behavior doi: 10.1038/s41467-018-05907-w recently, an international journal Nature In the Research Report on communications, scientists from the University of Uppsala and other institutions found that a special kind of cells may play a key role in the function of the hippocampus; when encountering danger or exciting events, people's responses are often different, even brothers and sisters will show great differences in risk-taking behavior, However, researchers are not clear about the neural mechanism behind this risk-taking behavior In this study, researchers found a special cell in the hippocampus, which plays a key role in risk-taking behavior and anxiety Researchers say that when the neuron cell named OLM is stimulated, it will produce a kind of brain rhythm, which exists when animals feel safe in a dangerous environment; for example, when animals avoid predators, they often realize that predators are approaching; anxiety and risk-taking behavior of the body can be controlled by manipulating OLM cells, looking for A fast and powerful way to regulate risk-taking behavior is essential for researchers to develop treatments for pathological anxiety disorders, because the risk reduction of risk-taking behavior in people with high anxiety level is often a feature of their disease performance 【8】 Jaacap: a single intervention may not be enough to treat anxiety disorder doi: 10.1016/j.jaac.2018.03.017 recently, a research report published in the International Journal of the American Academy of child and adolescent psychology, scientists from the University of Connecticut found that no matter what treatment they received, only 20% of them were diagnosed Young people with anxiety disorders can keep healthy for a long time Psychologist Golda Ginsburg said that when we receive the best treatment, only a small number of children will remain asymptomatic, which makes us very discouraged Compared with the current model, regular mental health examination may be a better way to treat anxiety In the study, researchers followed 319 young people aged 10 to 25, from California, North Carolina, Maryland and Pennsylvania, who were all diagnosed with isolation, social or general anxiety The researchers gave sertraline therapy or cognitive-behavioral therapy, or a combination of the two therapies, and then followed up the participants for four years each year Later, the researchers evaluated the anxiety level of the participants, but did not treat them Then, the researchers followed up the participants for one year, two years, five years and 10 years respectively, with a single follow-up For the first time in four years in a row, researchers evaluated participants treated for anxiety 【9】 Am j Psychiat: anxiety early marker of Alzheimer's disease doi: 10.1176/app i.ajp.2017.17040442 a recent study showed that there was a correlation between the increase of beta amyloid level and the deterioration of anxiety This result suggests that neuropsychological diseases may be able to reflect the risk of Alzheimer's disease in the elderly in advance Alzheimer's disease is a kind of neurodegenerative disease The main symptoms are the deterioration of cognitive function and the gradual loss of basic living ability Previous studies have shown that depression and other neuropsychological diseases may be able to predict the occurrence of Alzheimer's disease Researchers from brightam and women's Hospital tested the long-term changes of amyloid and depression in the brain, indicating that the higher the level of amyloid peptide, the more serious the symptoms of anxiety This result indicates that neuropsychological symptoms may be an early sign of Alzheimer's disease The related results are published in the American Journal of Psychiatry 【10】 Jbtep: sleeping less than 8 hours a day increases the risk of depression and anxiety disorder doi: 10.1016/j.jbtep.2017.10.003 according to a recent study by researchers from the University of Birmingham and the State University of New York, sleeping less than 8 hours can increase the risk of anxiety disorder and depression Meredith Coles, a professor in the Department of psychology at the University of Birmingham, and Jacob nota, a graduate student, collected information about people's sleep time and negative emotions The volunteers were asked to watch a series of different types of pictures to elicit emotional feedback, and then the researchers tracked their eye movements The results show that