Recent research progress of cell-based and its derivative hydrogels in the treatment of inflammatory diseases

Compared with traditional hydrogels, cell-based hydrogels and their derivatives have higher biological safety and diverse biological functions, involving multiple levels such as cells, proteins, and nucleic acids, and are widely used in diagnosis, treatment, Artificial skin and tissue engineering have achieved good therapeutic effects
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Advanced Healthcare Materials: Platelet-rich lysate plasma macroporous hydrogel scaffolds recruit endogenous M2 macrophages for long-term repair of articular cartilage defectsFigure 1 Schematic diagram of PLPMH scaffold preparation and recruitment of endogenous M2 macrophages to promote cartilage defect repair Comparative Culture of : In Vitro and In Vitro StudiesFigure 2 Schematic illustration of HPL/fibrin hydrogel preparation and HCEC encapsulation.
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Biomaterials Science: Inhibition of tumor recurrence and metastasis by surgical tumor-derived personalized hydrogel vaccineFigure 3 Schematic diagram of PTLDH preparation and PTLDH-mediated tumor immunotherapy for the prevention of postoperative tumor recurrence and metastasisFigure 4 Self-assembled RCT products form an intrinsically functional RNA G-tetracomplex (RG4) gel 5.
Scientific Reports: Human pancreatic ECM hydrogel optimizes 3D modeling of the islet microenvironmentFigure 5.
Decellularization and gelation protocol of human pancreatic ECMFig.
6 Synthesis and therapeutic principle of SVAP-exogenous PEG/DNA hybrid hydrogel for promoting vascularized bone regeneration in diabetes 7.
Biomaterials Advances: Dissolvable microgel-templated macroporous hydrogel controls cell assemblyFigure 7 Preparation and characterization of macroporous hydrogels 8.
International Journal of Molecular Sciences: Preparation of recombinant human collagen hydrogels with sustained release of extracellular vesicles and skin wound healingFigure 8 Preparation of rhCol III hydrogels 9.
Carbohydrate Polymers: a MnO2 nanozyme-enriched hyaluronic acid/platelet plasma hydrogel effectively relieves osteoarthritis in vivoFigure 9 Schematic diagram of HA/PRP/BM injectable hydrogel prepared by Schiff base reaction and its synergistic treatment of osteoarthritis 10.
ACS Applied Bio Materials: Construction of tunable tumors by recombinant bacterial collagen-hyaluronic acid hydrogel MicroenvironmentFigure 10 Schematic diagram of recombinant hybrid collagen-like protein (CLP) and norbornene-functionalized hyaluronic acid hydrogel (NorHA)