Radiology: Tumor-wide histogram analysis of multiple spread markers for glioma genotyping

In the 2016 World Health Organization (WHO) classification of tumors of the central nervous system, glioma genotype, rather than grade, was considered the most relevant information for neuroradiologists
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Isocitrate dehydrogenase (IDH) genotype and 1p/19q coding deletion status are two basic molecular markers that divide gliomas into three groups

In the 2016 World Health Organization (WHO) classification of tumors of the central nervous system, glioma genotype, rather than grade, was considered the most relevant information for neuroradiologists

At this stage , diffusion, perfusion, and metabolic MRI imaging techniques have been widely used in glioma genotyping studies

Recently, published in a journal Radiology study comparing the diagnostic accuracy of DTI, DKI, NODDI and MAP indicators predict WHO grade II and grade III glioma genotype of IDH and 1p / 19q encoding, and to assess the MAP in The application of glioma grading provides imaging technical support for preoperative non-invasive pathological evaluation of glioma

In this prospective study, participants were enrolled from December 2018 to December 2020

A total of 215 patients with grade II (n = 68), III (n = 35), and IV (n = 112) gliomas (115 men, 100 women; mean age, 48 years ± 13 [standard deviation]) were included .
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The blue line on the T2WI image shows the ROI of the lesion .

(A) 52-year-old female with WHO grade II oligodendroglioma with isocitrate dehydrogenase (IDH) mutation type and 1p/19q coding deletion .
(B) 52-year-old man with WHO grade II astrocytoma, IDH wild-type and 1p/19q noncoding region .

The blue line on the T2WI image shows the ROI of the lesion .
(A) 52-year-old female with WHO grade II oligodendroglioma with isocitrate dehydrogenase (IDH) mutation type and 1p/19q coding deletion .
(B) 52-year-old man with WHO grade II astrocytoma, IDH wild-type and 1p/19q noncoding region .
DKI=diffusion-kurtosis imaging, DTI=diffusion tensor imaging, FA=fraction anisotropy, ICVF=intracellular volume fraction, MAP=mean apparent communicator, NGRad=radial non-Gaussian, NODDI=neuronal orientation Dispersion and Densitometric Imaging, ODI = Orientation Dispersion Index, RK = Radial Kurtosis .
The blue line on the T2WI image shows the ROI of the lesion .
(A) 52-year-old female with WHO grade II oligodendroglioma with isocitrate dehydrogenase (IDH) mutation type and 1p/19q coding deletion .
(B) 52-year-old man with WHO grade II astrocytoma, IDH wild-type and 1p/19q noncoding region .
DKI=diffusion-kurtosis imaging, DTI=diffusion tensor imaging, FA=fraction anisotropy, ICVF=intracellular volume fraction, MAP=mean apparent communicator, NGRad=radial non-Gaussian, NODDI=neuronal orientation Dispersion and Densitometric Imaging, ODI = Orientation Dispersion Index, RK = Radial Kurtosis .
 

In conclusion, whole-tumor histogram analysis covering multiple markers of spread is a promising imaging method for glioma isocitrate dehydrogenase (IDH) and 1p/19q genotyping ; In predicting glioma IDH and 1p/ 19q genotyping, satisfactory diagnostic performance was achieved between various diffusion models, either individually or in combination .

In conclusion, whole-tumor histogram analysis covering multiple markers of spread is a promising imaging method for glioma isocitrate dehydrogenase (IDH) and 1p/19q genotyping ; In predicting glioma IDH and 1p/ 19q genotyping, satisfactory diagnostic performance was achieved between various diffusion models, either individually or in combination .

Original source :

Ankang Gao , Huiting Zhang , Xu Yan ,et al.

Whole-Tumor Histogram Analysis of Multiple Diffusion Metrics for Glioma Genotyping.
DOI: 10.
1148/radiol.
210820

Ankang Gao Huiting Zhang Xu Yan 10.
1148/radiol.
210820 Leave a message here