Radiology: The value of corpus callosum MRI in predicting dyskinesia in MS

The corpus callosum, the largest white matter tract, brings together the nerve fibers that connect the bilateral cerebral hemispheres, and its integrity is fundamental to the performance of cognitive tasks and the optimization of complex motor activity
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Thus , corpus callosum brain injury affects not only cognition but also overall motor performance and upper extremity motor function

The corpus callosum, the largest white matter tract, brings together the nerve fibers that connect the bilateral cerebral hemispheres, and its integrity is fundamental to the performance of cognitive tasks and the optimization of complex motor activity

It has been clinically found that corpus callosum damage is clinically associated with multiple sclerosis (MS)

A study published in the journal Radiology explored the relationship between structure on MRI and the functional stroma between the cerebral hemispheres in a large sample of MS patients across the spectrum of clinical disability and upper extremity dyskinesia .
To provide an imaging perspective for elucidating the role of corpus callosum lesions in MS .

This study retrospectively screened healthy control patients and patients with multiple sclerosis (between January 1, 2008, and December 31, 2016) from our institutional hospital database .
Clinical assessments included the Expanded Disability Status Scale (EDSS), the nine-hole nail test, and the digital finger tap test .
Using structural and resting- state functional MRI sequences, probabilistic maps of the fibers of the corticospinal tracts of the hand, as well as the hand motor cortex (hereafter referred to as hand M1), supplementary motor area (SMA), premotor cortex (PMC), and body were analyzed Transcortical fibers between prime mirror isotope junctions (VMHC) .
Random forest analysis identified different stages of clinical disability (EDSS score of 3.

We studied 130 healthy control patients (median age, 39 years; interquartile range, 31-50 years; 70 women) and 340 MS patients (median age, 43 years; interquartile range, 33 -51; 213 women)

 

Diagram of selected cortical regions and reconstructed white matter tracts .
(A) Cortical region of interest .
Primary hand motor cortex (hereafter referred to as hand M1) and supplementary motor areas (SMAs) were identified by using the Harvard-Oxford atlas, while premotor cortex (PMCs) were formed on Brodmann's area 6 in both cerebral hemispheres .
(B) White matter tracts reconstructed on anisotropic (FA) templates show midsagittal T1- and T2-weighted images of two multiple sclerosis patients with or without the Expanded Disability Status Scale (EDSS) degree .
The first row shows hand-related fibers of the corticospinal tract, the second row shows Hand-M1 percutaneous fibers, the third row shows PMC percutaneous fibers, and the fourth row shows SMA percutaneous fibers .
Color coding indicates local fiber orientation (red, left-right; green, dorsal-ventral; blue, head - foot ) .
A=front, L=left, P=rear, R=right .
 

Diagram of selected cortical regions and reconstructed white matter tracts .

(A) Cortical region of interest .
Primary hand motor cortex (hereafter referred to as hand M1) and supplementary motor areas (SMAs) were identified by using the Harvard-Oxford atlas, while premotor cortex (PMCs) were formed on Brodmann's area 6 in both cerebral hemispheres .
(B) White matter tracts reconstructed on anisotropic (FA) templates show midsagittal T1- and T2-weighted images of two multiple sclerosis patients with or without the Expanded Disability Status Scale (EDSS) degree .
The first row shows hand-related fibers of the corticospinal tract, the second row shows Hand-M1 percutaneous fibers, the third row shows PMC percutaneous fibers, and the fourth row shows SMA percutaneous fibers .
Color coding indicates local fiber orientation (red, left-right; green, dorsal-ventral; blue, head - foot ) .
A=front, L=left, P=rear, R=right .
 Diagram of selected cortical regions and reconstructed white matter tracts .
(A) Cortical region of interest .
Primary hand motor cortex (hereafter referred to as hand M1) and supplementary motor areas (SMAs) were identified by using the Harvard-Oxford atlas, while premotor cortex (PMCs) were formed on Brodmann's area 6 in both cerebral hemispheres .
(B) White matter tracts reconstructed on anisotropic (FA) templates show midsagittal T1- and T2-weighted images of two multiple sclerosis patients with or without the Expanded Disability Status Scale (EDSS) degree

In conclusion, on MRI, structural abnormalities of premotor and motor white matter fibers can predict the severity of dyskinesia in patients with multiple sclerosis

Original source :

Claudio Cordani , Paolo Preziosa , Paola Valsasina , et al.

MRI of Transcallosal White Matter Helps to Predict Motor Impairment in Multiple Sclerosis.
DOI: 10.
1148/radiol.
2021210922

Claudio Cordani Paolo Preziosa Paola Valsasina ,et al 10.
1148/radiol.
2021210922 10.
1148/radiol.
2021210922Leave a message here