Radiology: For patients with acute ischemic stroke, this imaging indicator can indicate prognosis!

In acute ischemic stroke (AIS), regional venous oxygen saturation (SvO ₂ ) in brain tissue decreases due to a reduction in regional cerebral blood flow
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Brain function is particularly sensitive to changes in oxygen saturation, and irreversible damage can occur if prolonged hypoxia occurs .

In acute ischemic stroke (AIS), regional venous oxygen saturation in brain tissue (SvO stroke ₂ 2 ) decreases due to a reduction in regional cerebral blood flow

According to several studies , asymmetric cortical veins (APCVs) are associated with decreased oxygen saturation

Recently, a study published in the journal Radiology applied QSM to longitudinally quantify SvO2 in acute ischemic stroke brain MRI, quantitatively analyze its changes in 2-week follow-up after standardized treatment , and further evaluate the effect of SvO2 on clinical outcomes .
The impact of prognosis provides valuable imaging technical support for early clinical assessment of AIS .

Between 2016 and 2020, this study retrospectively enrolled patients with AIS who underwent brain MRI scans within 24 hours of symptom onset and within 2 weeks of treatment .

_The SvO2 of APCV was quantified using QSM .

Between 2016 and 2020, this study retrospectively enrolled patients with AIS who underwent brain MRI scans within 24 hours of symptom onset and within 2 weeks of treatment .
The SvO ₂ 2 of APCV was quantified using QSM .
Independent samples t-test was used to compare SvO ₂ 2 in patients with and without APCVs .
Paired samples t-tests were used to assess the dynamics of SvO ₂ 2 .
Pearson and Spearman correlation analysis was used to explore the relationship between dynamic changes in SvO ₂ 2 and hypoperfusion, changes in NIHSS scores, and 90-day modified Rankin Scale (mRS) scores .
Independent samples t-test was used to compare the dynamic changes of SvO ₂ 2 between different clinical prognosis and outcome subgroups .

APCV was detected on admission in 39 of 73 patients (mean age 70 years ± 10 [standard deviation]; 49 males) and disappeared on 2-week follow-up MRI in 35 patients

 

Figure scatter plot showing dynamic changes in venous oxygen saturation (SvO ₂ ) versus (A) time to maximum volume exceeding 6 s (Tmax > 6 s), (B) changes in NIHSS, and (C) correction of disappearance after treatment Correlation of Rankin Scale (mRS) scores at 90 days .

 

Figure scatter plot showing dynamic changes in venous oxygen saturation (SvO ₂ ) versus (A) time to maximum volume exceeding 6 s (Tmax > 6 s), (B) changes in NIHSS, and (C) correction of disappearance after treatment Correlation of Rankin Scale (mRS) scores at 90 days .

In conclusion, this feasibility study shows that the dynamic changes of APCVs can reflect the oxygen utilization and regulation after acute ischemic stroke (AIS), and the improvement of cerebral venous oxygen saturation (SvO ₂ 2 ) in patients with AIS is related to APCVs at follow-up The prognosis of the disappearing patients echoed well .
Although our study samples varied widely in clinical presentation and treatment, this study could consistently detect an increase in SvO2 across the entire APCVs area , _{demonstrating} the real - world feasibility and applicability of using QSM to monitor _SvO2 .

Original source :

Xiudi Lu , Yu Luo , Miller Fawaz , et al .

Dynamic Changes of Asymmetric Cortical Veins Relate to Neurologic Prognosis in Acute Ischemic Stroke .
DOI: 10.

Xiudi Lu Yu Luo Miller Fawaz ,et al Dynamic Changes of Asymmetric Cortical Veins Relate to Neurologic Prognosis in Acute Ischemic Stroke 10.
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