Radiology: For children with tumors, don't always think about CT!

 At this stage, advances in childhood cancer treatment have allowed more and more children with cancer to survive, so that some children will encounter secondary cancer during a longer survival period
.

Studies have shown that diagnostic imaging techniques with radiation exposure are associated with the risk of inducing secondary cancer

 At this stage, advances in childhood cancer treatment have allowed more and more children with cancer to survive, so that some children will encounter secondary cancer during a longer survival period

The evaluation of tumor treatment response often requires tumor metabolism information, which can be obtained through FDG PET examination

Recently, a study published in the journal Radiology compared the efficacy of whole-body DW MRI and FDG PET/MRI in evaluating tumor response in children and young people, providing imaging for early clinical, accurate and safe evaluation of tumor response.

There is a good agreement between whole body DW MRI and FDG PET/MRI in the evaluation of treatment response after induction chemotherapy (α = 0.
88)
.

Based on the maximum SUV (AUC= 100%; 95% confidence interval [CI]: 99%, 100%) and the minimum ADC (AUC= 98%; 95% CI: 94%, 100%) to predict the results of clinical treatment response Similar (P = .

The results of predicting clinical treatment response based on the maximum SUV and minimum ADC are similar .

Figure 1 The consistent information of ¹⁸ F FDG PET/MRI and whole body (WB) DW MRI in monitoring the treatment of diffuse large B-cell lymphoma
.

A 13-year-old man with diffuse large B-cell lymphoma.

Figure 1 The consistent information of ¹⁸ F FDG PET/MRI and whole body (WB) DW MRI in monitoring the treatment of diffuse large B-cell lymphoma

Figure 2 For different cut-off values ​​of tumor maximum normalized uptake value (SUV) and tumor minimum apparent diffusion coefficient (ADC), the true positive rate (sensitivity) of the receiver operating characteristic curve is regarded as the false positive rate (1-specificity) Function drawing
.

There was no significant difference between the maximum SUV change (100%; 95% CI: 99%, 100%) and the minimum ADC change (98%; 95% CI: 94%, 100%) in predicting clinical treatment response (P = .

Figure 2 For different cut-off values ​​of tumor maximum normalized uptake value (SUV) and tumor minimum apparent diffusion coefficient (ADC), the true positive rate (sensitivity) of the receiver operating characteristic curve is regarded as the false positive rate (1-specificity) Function drawing

In summary, this study proves that whole-body diffusion-weighted MRI can help clinically evaluate the response of children's tumors, especially in lymphoma and sarcoma patients 8-12 weeks after starting treatment

Original source:

Ashok J Theruvath , Florian Siedek , Anne M Muehe , et al.

J Theruvath ashok , Florian Siedek , Anne Muehe M , et Al.
Therapy with the Response Assessment of Pediatric Tumors Whole-Body Diffusion Weighted-FDG the MRI and the PET / the MRI .
The DOI: 10.
1148 / radiol.
2020192508 10.
1148 / radiol.
2020192508 in this message