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Tumor growth is a complex process that requires tissue vascular supply for nutrients and oxygen uptake
.
This process is greatly affected by hypoxia and can induce abnormal vascularization and epithelial-mesenchymal transition, both of which are conducive to the metastatic spread of cancer cells
Tumor growth is a complex process that requires tissue vascular supply for nutrients and oxygen uptake
Dual-energy CT provides an interesting approach for assessing angiogenic aspects of lung tumors .
Several recently published studies have shown that dual-energy CT can obtain mean iodine concentration measurements throughout the tumor volume to predict the effect of tumor chemotherapy and further reflect its relationship with postoperative prognosis .
Dual-energy CT can obtain mean iodine concentration measurements throughout the tumor volume to predict the effect of tumor chemotherapy and further reflect its relationship with postoperative prognosis .
However , to the best of our knowledge, studies on the relationship between lung tumor hypoxia and dual-energy CT parameters are still insufficient .
Recently, a study published in the journal Radiology analyzed the dual-energy CT perfusion characteristics of non-small cell lung cancer according to the degree of tumor hypoxia, providing more intuitive imaging support for the evaluation of the efficacy and prognosis of lung cancer
.
.
This prospective study performed two -phase dual-energy CT scans in consecutive participants with operable non-small cell lung cancer during 2016-2017 .
Transient and delayed iodine concentrations and normalized iodine uptake were calculated for the entire tumor and within three automatically segmented peripheral layers (i.
e.
, 2 mm thick concentric subvolumes), corresponding to the intratumoral iodine concentration normalized to the primary iodine concentration.
Iodine concentration in arteries .
This prospective study performed two -phase dual-energy CT scans in consecutive participants with operable non-small cell lung cancer during 2016-2017 .
Transient and delayed iodine concentrations and normalized iodine uptake were calculated for the entire tumor and within three automatically segmented peripheral layers (i.
e.
, 2 mm thick concentric subvolumes), corresponding to the intratumoral iodine concentration normalized to the primary iodine concentration.
Iodine concentration in arteries .
There were 33 mCA IX-positive tumors and 16 mCA IX-negative tumors
Figure 79-year-old female with adenocarcinoma of the right upper lobe who underwent dual-energy CT angiography scan before surgery .
(A) Mediastinum and (B) corresponding lung CT slices were obtained at the level of maximum tumor diameter , showing tumor segmentation .
Segmented tumor volumes are shown in purple .
(A) Mediastinum and (B) corresponding lung CT slices were obtained at the level of maximum tumor diameter , showing tumor segmentation .
Segmented tumor volumes are shown in purple .
Figure 79-year-old female with adenocarcinoma of the right upper lobe who underwent dual-energy CT angiography scan before surgery .
(A) Mediastinum and (B) corresponding lung CT slices were obtained at the level of maximum tumor diameter , showing tumor segmentation .
Segmented tumor volumes are shown in purple .
In conclusion, this study demonstrates that dual- phase dual-energy CT examination can provide information on lung tumor perfusion by identifying functional neovascular areas between lung parenchyma and tumor , enabling in vivo insight into the forefront of tumor invasion , providing insights into tumor invasion in vivo.
Treatment and evaluation provide a reference basis .
In conclusion, this study demonstrates that dual- phase dual-energy CT examination can provide information on lung tumor perfusion by identifying functional neovascular areas between lung parenchyma and tumor , enabling in vivo insight into the forefront of tumor invasion , providing insights into tumor invasion in vivo.
Treatment and evaluation provide a reference basis .
Original source :
Original source :Julie Dewaguet , Marie-Christine Copin , Alain Duhamel , et al.
Dual-Energy CT Perfusion of Invasive Tumor Front in Non-Small Cell Lung Cancers.
Julie Dewaguet Marie-Christine Copin Alain Duhamel 10.
1148/radiol.
2021210600.
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