Radiology: Brain White MRI Imaging Technology - Direct Imaging of Myelin

Background
It is challenging to directly image myelin with MRI due to signal contamination of water-containing t2Eliminating non-essential long T2 signals can be achieved by flipping recovery (IR) pre-pulses to achieve the long T2 signal of intracranial brain white matterMyelin lipids with ultra-short T2 signals can be imaged by ultra-short echo time (UTE)The purpose of this study was to perform patient-based whole-brain myelin phospholipid imaging using a 3D dual echo sliding recovery (DESIRE) UTE sequencematerials and methods
the DESIRE UTE series is formed using combined IR imaging for different flip times in a single scanThe lowest signal in the secondary echo determines the best flip time to eliminate the long T2 signalThe UTE image is obtained by silhouetteof the first UTE image and the second echo imageTo verify the feasibility of this method, prospective scanning and analysis was carried out using molds, cranial brain specimens, healthy volunteers and patients with multiple sclerosis (MS)The study included 20 healthy volunteers and 20 MS patients for MRIThe signal difference between MS lesions and normal brain white matter was evaluated by variance analysisresults
high signals in myelin and related T2 and T1 values fully demonstrate that the use of UTE sequence can directly image myelin of ultra-short T2 signals The DESIRE UTE sequence can be used to suppress different T1 value signals of the molybnop plymine mold In the in vitro brain tissue MS lesions trial, it was found that THE missing MS signal was consistent with the results of histology analysis In human body tests Compared to normal brain white matter, ms lesions signal significantly reduced (0.19 s 0.10 vs 0.76 s 0.11, onlyly; P .001) conclusion
the surface of this study can be used to image the whole brain myelin phospholipids by using double echo sliding flips to recover the ultra-short echo time sequence