Radiat Oncol: Low-level laser treatment for head and neck tumor mucositis

Low-level laser therapy (LLLT), also known as photobiotic therapy (PBMT), can reduce the incidence and severity of oral mucositis (OM) in patients with head and neck cancer who receive chemical radiotherapy, but there is currently a lack of randomized data on efficacy and safety, with a treatment dose of 4J/cm2the Phase III trial was conducted in patients with oral cancer, pharynx cancer (Phase III or Stage IV)During radiotherapy, the patient was lasertreated with ANO lesions level 2 (4 J/cm2 or placebo) until recoveryThe severity of OM (the incidence and duration of level 3) was the main endpoint and was evaluated by the blind methodresults, of the 97 random patients, 83 (85.6%) were eventually assessed and 32 patients were not laser-treated because THE OM lesions could not arriveRandomized and demographic characteristics (gender ratio, age, radiotherapy procedure, incidence of poisons) in the LLLT/PBMT groups were still comparableAcute OM (Grade 3) observed in 41 patients (49.4%): 23 patients in the active laser group (54.8%) and 18 patients in the control group (43.9%) (correction intended treatment, p.0.32)Half of the patients had a median time before OM-level 3, and the active laser group had 8 weeks (9 weeks for the control group)However, 95% of patients showed very good tolerance to LLLT/PBMTin general, the study evaluated LLLT/PBMT on the recommendation of the Multi-National Association for Cancer Complementary Treatment, but lacked motivationLLLT/PBMT is well tolerated and safe, facilitating its use in clinical practice for critical OM treatment