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Put down your burger and fries!

 Last Update: 2022-05-20
 Source: Internet
 Author: User

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Breast cancer (BC) is a common female tumor, accounting for about 25% of all female malignant tumors, with 1 million new cases worldwide each year

However, BC age-related mortality rates are declining in high-income countries, while mortality rates are rising in low-income countries

Among the different types of BC, invasive ductal carcinoma (IDC) and lobular carcinoma (ILC) are the 1st and 2nd most common breast cancers (75% and 15% of all breast malignancies, respectively)

In addition, the risk of distant recurrence in ILC patients tends to exceed 5-10 years compared with IDC, and the risk of distal recurrence in ILC patients tends to exceed 5-10 years compared with IDC The risk often exceeds 5-10 years, and ILC is also considered to be less sensitive to chemotherapy with adjuvant or neoadjuvant chemotherapy

Regarding the effect of diet on BC risk, many studies have measured the association between single foods and BC risk

We have known for years that WD is potentially harmful to our health

The mean (±standard deviation [SD]) age was 48.

In addition, IDC and ILC patients were more likely to be smokers (14% and 15%, respectively) than controls (7%) (p < 0.

Table 2 lists general characteristics and dietary information of Western dietary patterns

Estimated ORs for adherence to WD patterns in IDC patients are shown in Table 3

Furthermore, the test for linear trend in WD adherence was significant (p-trend < 0.

Table 3 shows the estimated ORs for WD pattern adherence and ILC breast cancer risk, finding that higher adherence to the WD pattern was not associated with ILC risk in both Model 1 and Model 2 (Model 2: OR highest vs lowest tertile : 1.
63, 95% CI 0.
63, 3.
25, p for trend = 0.
06)
.
A test of heterogeneity comparing the association of WD adherence with IDC and ILC risk was also significant (p heterogeneity = 0.
03)
.

Stratification results based on menopausal status are shown in Table 3
.
Thus, in premenopausal women, higher adherence to the WD pattern was associated with an increased risk of IDC (Model 2: OR highest vs lowest tertile: 2.
95, 95% CI 1.
91, 4.
56; p for trend p<0.
001)
.
However, the results of ILC were similar to those of ILD, but not statistically significant
.
Among menopausal women, higher adherence to the WD pattern was associated with an increased risk of IDC (Model 2: OR highest vs lowest tertile: 2.
16, 95% CI 1.
39, 3.
37), but not statistically significant for ILC ( Mode 2: OR highest vs lowest tertile: 1.
35, 95% CI 0.
64, 2.
85) (p for heterogeneity = 0.
04)
.

Findings were also consistent with overall results when results were stratified by smoking status or BMI, suggesting that higher adherence to WD, in addition to smoking status or BMI, was a risk factor for IDC, but not for ILC
.
No significant interaction was found between the study variables (including smoking status) and menopause status ( all interactions p ≥ 0.
05 )
.
Furthermore, there was no apparent collinearity between WD scores and any other factors
.

The results of this study showed that there was significant heterogeneity in the association of WD with IDC risk and ILC, and there was a positive correlation between WD and IDC risk
.
Overall, WD was associated with a 2.
45-fold increased risk of IDC
.
The results for premenopausal and postmenopausal women were consistent with the overall results
.
Given the importance and strength associated with WD patterns, in order to determine which dietary habits should be recommended and which ones should be avoided to reduce BC risk, it is important to focus not only on the potential protective effects of healthy eating patterns, but also on the harmful components of the Western diet
.

The results of this study showed that there was significant heterogeneity in the association of WD with IDC risk and ILC, and there was a positive correlation between WD and IDC risk
.
Overall, WD was associated with a 2.
45-fold increased risk of IDC
.
Results for premenopausal and postmenopausal women were consistent with overall results
.
The results for premenopausal and postmenopausal women were consistent with the overall results
.
Given the importance and strength associated with WD patterns, in order to determine which dietary habits should be recommended and which ones should be avoided to reduce BC risk, it is important to focus not only on the potential protective effects of healthy eating patterns, but also on the harmful components of the Western diet
.

Original source:

Foroozani E, Akbari A, Amanat S, et al.
Adherence to a western dietary pattern and risk of invasive ductal and lobular breast carcinomas: a case-control study.
Sci Rep .
2022;12(1):5859.
Published 2022 Apr 7 .
doi: 10.
1038/s41598-022-09725-5.

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