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PSMA is unstoppable, fancy playing immunotherapy

 Last Update: 2021-12-05
 Source: Internet
 Author: User

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Prostate cancer is one of the most common malignant tumors in European and American countries
.

With the improvement of China's economic level and the change of residents' life>
.

PSMA is not only highly expressed in advanced and castration-resistant prostate cancer, but the large extracellular domain makes it a perfect target for immune methods
.

In addition, the results of PSMA targeted radionuclide therapy also confirmed that it is an ideal target for the diagnosis and treatment of prostate cancer
.

For the treatment of advanced prostate cancer, androgen deprivation therapy (ADT) is still the first-line therapy, but advanced prostate cancer often develops metastasis or castration resistance, and then develops into castration-resistant prostate cancer (CRPC, Castrate-Resistant Prostate Cancer)
.

For CRPC, androgen receptor blockers (AR) such as abiraterone and enzalutamide have been widely used clinically, but the remission rate is limited
.

Therefore, more therapies for PSMA need to be explored
.

At present, immunotherapy targeting PSMA has entered the clinic, and it is expected to provide new drug options for patients with advanced castration-resistant prostate cancer in the future
.

Targeted PSMA immunotherapy is mainly divided into the following categories: antibody-drug conjugates (ADC), chimeric antigen receptor T cells (CAR-T), and bispecific T cell redirection therapy
.

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