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The mitochondria are the cell's power device, which is coupled with another process called oxidative phosphorylation through an electrochemical process called the electron transport chain to produce most of the energy required by the cell
"This study comprehensively quantifies the electron transport chain proteins in the super-complex and their response to exercise training
Traditional methods provide too little detail
Exercise training stimulates the quality of mitochondria and affects the formation of super-complexes, which has been fully proven to enable mitochondria in skeletal muscle to produce energy more efficiently
In order to better understand the formation of supercomplexes, especially in response to exercise, the team of scientists studied two groups of mice
When scientists typically analyze how supercomplexes are formed, they use antibodies to measure one or two proteins in each electron transport chain complex
"It is known that the protein content of mitochondria increases with exercise, so understanding how these proteins assemble into supercomplexes is critical to deciphering how they work
Interdisciplinary projects are Deshmukh, the Treebak and Zierath groups of CBMR, and the Mann group of the Novo Nordisk Foundation Protein Research Center
Journal Reference :
Alba Gonzalez-Franquesa, Ben Stocks, Sabina Chubanava, Helle B.
