Proteins for wound healing

Mice that lack two important proteins in the vascular system develop normally and appear to be healthy in adulthood without injury, according to a new study But if they get hurt, they don't heal well When an organ is injured, the healing process involves the growth of new blood vessels Because vascular endothelial cells and blood cells themselves are very important for the development of new blood vessels, ornitz and his colleagues want to know what happens if they turn off the signals of FGFR1 and FGFR2 proteins, the two main mediators of FGF signals present in vascular endothelial cells? Their strategy is to turn off the signal more widely than previous studies "The first thing we noticed - and quite surprising to us at the same time - was that mice were completely normal," ornitz said They run from place to place and live to old age We did genetic testing to make sure that they really lacked these proteins But when we challenged these mice, we found that their injured skin healed more slowly and the density of blood vessels around the injured area decreased significantly compared to littered animals " ELISA Kit The researchers also looked at the eyes of the mice Like any other organ, there are new blood vessels growing in the eye to cope with disease or injury But unlike other parts of the body, new blood vessels here are not ideal because they bleed, causing scar tissue to form and prevent light from reaching the retina, causing vision loss New research shows that the increased FGF signal in human body can help wound healing by increasing the growth of new blood vessels after injury Especially those who have trouble healing wounds, such as diabetic foot ulcers Ornitz points out that in Japan, human FGF2 has been used as a local spray for foot ulcers and similar wound healing in clinic On the contrary, inhibition of these pathways in the eyes may help patients with age-related macular degeneration or diabetic retinopathy These patients produce new blood vessels to deal with these lesions or damaged conditions, but the new blood vessels are only used to block the vision, and can not help cure the abnormal diseases ELISA Kit Because studies have shown that these FGF pathways are not involved in abnormal development and tissue maintenance, any treatment that promotes or suppresses these signals may not affect healthy tissues This is an important point In diabetes, normal blood vessels in the retina become vulnerable due to disease With any kind of targeted therapy, we are worried about destroying normal blood vessels ELISA kit but our research shows that inhibiting the FGF signal in the eyes can prevent this abnormal response without damaging the normal blood vessels "