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protein synthesis journey

 Last Update: 2022-05-16
 Source: Internet
 Author: User

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The genetic information stored in DNA is "decoded" into proteins through the process of translation

Although the evolution of PTC formation has been thoroughly documented, how ribosomes develop into functional entities and become essential components of protein synthesis is poorly understood

A team of scientists at Tokyo University of Science, led by Professor Koji Tamura, decided to solve this puzzle with the lens of biological evolutionary continuity

The idea arose after a closer look at the crystal structure of the 70S ribosome-tRNA complex in Thermus thermophilus, a bacterium often used in genetic studies

They first attempted to form peptide bonds between two alanine-specific small helices in the presence of fragments of ribosomal RNA

This finding undoubtedly hints at the possibility that the small helix binds to the original PTC

Future applications of this research -- opening exciting avenues for evolutionary RNA biology -- are manifold

Mai Kawabata, Kentaro Kawashima, Hiromi Mutsuro-Aoki, Tadashi Ando, Takuya Umehara, Koji Tamura.

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