Protein engineering helps to improve the effect of mRNA therapy
-
Last Update: 2018-04-01
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
April 1, 2018 / BIOON / -- mRNA drugs are believed to help deliver therapeutic protein molecules According to a recent study published in the Journal of nuclear acid therapeutics, more stable and more active proteins can be obtained through the engineering design method, thus further improving the potential of mRNA therapy Specifically, some specific sequence design can improve the expression of target protein, the time of existence and enzyme activity (photo source: Com) the study is called "leveraging rational protein engineering to improve mRNA therapeutics" by romesh Subramanian and other colleagues from alexion pharmaceuticals in Cambridge, USA The researchers say the expression of the engineered specific protein sequence and its positive effect have been verified at the mouse level Sequence engineering design can improve the thermochemical stability and therapeutic activity of protein "The development of protein variants that improve their stability and activity can reduce the dosage of the drug, thereby alleviating the complications of the patients after the medication," said Graham C Parker, executive editor of the Department of pediatrics at Wayne State University School of medicine in the United States Information source: rational protein engineering can improve effectiveness of mRNA therapies
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
