Protective effect of Atractylodes macrocephala extract on gastric mucosa

Recently, researchers from Hubei University of nationalities published papers to explore the protective effect of Rhizoma Atractylodes extract (ERA) on gastric mucosa and the effect on gastrointestinal immune function of spleen deficiency model rats, and to clarify the mechanism of era intervention on spleen deficiency syndrome The results showed that era could inhibit the damage of gastric mucosa, protect and repair the damaged mucosa, and improve the immune function of spleen deficiency rats This article was published in the 3rd issue of Journal of Southern Medical University in 2015 The spleen deficiency model of rats was established by feeding Xiaochengqi Decoction and starvation and satiety disorder The rats were randomly divided into spleen deficiency model group, era high, medium and low dose group and domperidone group The drug was administered by gavage for 10 days The content of IgA in intestinal perfusion fluid and IgG in serum of rats were measured by intestinal perfusion method, and the indexes of thymus and spleen were measured by abdominal aortic blood sampling method The pathological observation of gastric mucosa was performed by HE staining, the blood flow of gastric mucosa was measured by laser Doppler microcirculation flowmeter, and the expression of TFF1 and TLR4 in gastric mucosa was measured by immunohistochemistry Compared with the normal group, the morphology of gastric mucosa, the blood flow of gastric mucosa and the related immunological indexes in the model group were significantly changed; compared with the model group, the morphology of gastric mucosa, the blood flow of gastric mucosa, the expression of TFF1 in gastric mucosa, IgA and serum Ig in intestinal perfusion fluid of rats in each dose group of era were significantly changed The levels of G, thymus, spleen index and TLR4 expression in colon increased in different degrees, and the differences were statistically significant (P < 0.05 or P < 0.01).