Prostate male patients with prostate prostate in the prostate of atovastatin entry pathways and concentrations

Statins have anti-cancer effects on prostate cancer both in and around the body!----it is not clear whether this is due to systemic cholesterol reduction or direct inhibition of local prostate growthwhether statins can enter the prostate is also unclear, in theory, lifat statins can passively spread through the lipid-rich cell membranehowever, the concentration of statins in the human prostate has not been measured beforestudy based on a randomized clinical trial in which 158 men with prostate cancer randomly used 80 mg of atovastatin (ATV) or placebo for a median of 27 days before a root-and-desismytomyectomyuse mass spectrometers to measure the concentrations of ATV and ATV-Lactone in the plasma and prostate of men randomly to the ATV groupstudy the linear trends between intraprostate concentration and plasma concentration, body mass index, age and intervention timecalculate the relative tissue concentration of ATV and ATV-Lactone in prostate tissue and plasma to assess drug balancesubgroup analysis was stratified by tumor and demographic characteristicsresults, the study included a total of 55 menthe median ATV concentration in the tissue is 212% higher (median concentration 17.6 ng/g) than plasma (median concentration 3.6 ng/mL) in men with a measured tissue concentration limited to a TV (n s 28,50%), the aTV-L concentration in the tissue was 590% higher than the plasma concentrationThere is no statistically linear trend betweenplasma and tissue concentrationwhen comparing the relative concentration of atorvastatineste higher than ATV, the concentration in the plasma was in equilibrium, however, in the prostate, the relative concentration of atovastatine was 57% lower than ATV (the difference between prostate tissue and plasma was P.009)no effect on the effects of tumors or population characteristics was observed , the results show that the measurable ATV concentration in the prostate supports the ability of ATV to enter the prostate from the circulation ATV may accumulate in the prostate because the concentration in the prostate is higher than the plasma concentration