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Promising to improve standard treatment of psoriatic arthritis!

 Last Update: 2022-02-18
 Source: Internet
 Author: User

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On January 21, 2022, UCB (UCB) announced that the second Phase 3 clinical trial of the IL-17A/F inhibitor Bimzelx (bimekizumab) in the treatment of active psoriatic arthritis (PsA) achieved positive top-line results

PsA is a chronic inflammatory disease that causes irreversible joint deformity and disability

The fully humanized monoclonal antibody bimekizumab can potently and specifically neutralize IL-17A and IL-17F

▲Schematic diagram of the working mechanism of Bimekizumab (Image source: Reference [2])

A total of 400 subjects were enrolled in this randomized, double-blind, multicenter, placebo-controlled Phase 3 clinical trial

The study also met all important secondary endpoints

In terms of safety, the safety characteristics of bimekizumab in the trial were consistent with previous studies, and no new safety signals were observed

References:

[1] Positive Top-Line Results for Bimzelx[®]▼(bimekizumab) in Second Phase 3 Psoriatic Arthritis Study.

[2] Bimekizumab Overview.

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