Progress in the study of chemical and active components of Valeriana officinalis in Kunming Institute of Botany

Valeriana officinalis Linn Is a Valeriana plant of valerianaceae family Its root is used as medicine, mainly for the treatment of restlessness, palpitation and insomnia At present, it is mainly used for sedative and hypnotic drugs in European and American countries It has no hangover effect, and has been newly recorded in the United States and European Pharmacopoeia It is sold in European and American markets There is no large amount of cultivation in China except for this research group European products directly use valerian root crushed capsules, and American products use crude extracts Valerenic acid is often used as quality control index in European and American Pharmacopoeia, and valerian in China cannot enter European and American market due to lack of this component There are mainly v officinalis L var latifolia, V pseudoficinalis C.Y Cheng et h.b.chen, V amurensis Smir Ex Kom, among them, Valeriana officinalis L var latifolia, V pseudoficinalis C.Y Cheng et h.b.chen, V amurensis Smir Ex Kom, etc widely used as valerian for sedation and sleeping, which has been planted according to gap regulations in Hubei and Guizhou The clinical efficacy of Valeriana officinalis in sedation and sleeping is accurate, and it has a long history in Europe, but the effective ingredients are still controversial In order to develop Valeriana officinalis into a calming and sleeping functional food, Zhou Jun research group of Kunming Institute of Botany, Chinese Academy of Sciences successfully introduced Valeriana officinalis seeds from Germany in 2006 Nearly 100 kg of Valeriana officinalis dry roots have been obtained by expanding cultivation In addition, tissue culture and rapid propagation have also been successful, and 4 Mu has been expanded The introduced and cultivated Valeriana officinalis L was identified by Professor Chen Hubiao of Peking University and compared with Valeriana officinalis L produced in Germany by HPLC The study group cooperated with Yunnan Institute of medicine to screen and found that Valeriana officinalis ethanol extract has mild sedative, hypnotic and antidepressant effects Wang Pengcheng, a doctoral student under the guidance of academician Zhou Jun, conducted a systematic study on the chemical constituents of the introduced and cultivated Valeriana officinalis and the substitute of Valeriana officinalis in China, with the support of the independent research project (p2008-zz22) of the State Key Laboratory of Phytochemistry and sustainable utilization of plant resources in the West of Kunming Institute of Botany and the project entrusted by the enterprise More than 80 monomers were isolated and identified Among them, there are 31 sesquiterpenes and sesquiterpenes dimers, including 17 new compounds It was found that the three sesquiterpenes at 50mg / kg could significantly shorten the immobility time of tail suspension and forced swimming in mice, indicating a certain antidepressant activity The differentiation and ache inhibitory activity of some monomers were studied Five compounds showed ache inhibitory activity and enhanced differentiation activity of nerve cells This study has laid a solid foundation for the elucidation of the mechanism of action of Valeriana officinalis and Valeriana officinalis as well as for the development of drugs and functional foods, and has certain scientific significance for promoting the effective utilization of Valeriana plant resources in China.