Progress in the mechanism of Arctium lappa in the treatment of tumor

Business news on August 9: selective killing of tumor cells to reduce the damage to normal tissue is a major challenge for the current treatment of tumor strategy Studies have shown that due to the rapid proliferation of tumor cells, solid tumor cells are usually in a state of oxygen, glucose or other nutrients deficiency Therefore, targeting glucose deficient tumor cells may be a new strategy to selectively kill tumor cells Arctiin is the main active component of Arctium lappa L The existing research shows that arctiin has antitumor activity and can effectively inhibit tumor growth in a variety of tumor models Yu Qiang research group of Shanghai Institute of medicine, Chinese Academy of Sciences has conducted in-depth study on the anti-tumor mechanism of arctigenin It is found that under the condition of glucose deficiency, arctigenin can cause the decrease of ATP level and the increase of active oxygen group level in tumor cells by inhibiting mitochondrial respiration, thus promoting the death of tumor cells It was also found that arctigenin combined with 2-deoxy-D-glucose, a glycolysis inhibitor, can selectively kill tumor cells, but has low toxicity to normal cells The research results provide a new basis and strategy for the treatment of tumor with traditional Chinese medicine Relevant papers have been published online in the Journal of biological pharmacology The research was supported by the National Natural Science Foundation of China and major national science and technology projects.