Progress in Metz Neurology (Issue 005)

Editor's note: Metz Medicine will regularly summarize the latest developments in the neurological field

Editor's note: Metz Medicine will regularly summarize the latest developments in the neurological field

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For details in previous issues:

For details in previous issues:

Progress in Metz Neurology (Issue 004)

Progress in Metz Neurology (Issue 004)

Progress in Metz Neurology (Issue 003 )

Advances in Metz Neurology (Issue 003 ) Advances in Metz Neurology (Issue 003 ) 003

Progress in Metz Neurology (Issue 002 )

Advances in Metz Neurology (Issue 002 )

Advances in Metz Neurology (Issue 001 ) Advances in Metz Neurology (Issue 001 )

1.

1.

Recently, a study published in JAMA Psychiatry analyzed the correlation between the development of cerebral cortex thickness assessed by magnetic resonance (MR) imaging and cannabis use

Longitudinal analysis shows that age-related cortical thinning is limited by cannabis use in a dose-dependent manner, so from baseline to follow-up, more cannabis use is associated with increased left and right prefrontal cortex thinning

For details, please refer to: JAMA Psychiatry: Look at the association between marijuana smoking during adolescence and neurodevelopment.

2.

Recently, a study led by a team from the University of Cambridge in the United Kingdom and published in the journal Alzheimer & Dementia conducted a comprehensive analysis of whether apathy can predict changes in the cognitive function of asymptomatic FTD patients

The researchers included asymptomatic carriers of MAPT, GRN, or C9orf72 mutations (N = 304) and relatives without mutations (N = 296) who underwent clinical evaluation and MRI at baseline, and were examined annually for 2 years

The baseline CBI-R indifference score was further used as a predictor of the numerical symbol longitudinal scoring model for model construction, and it was found that the model fits well with the data (χ2 = 29.

For details, please refer to: Alzheimer & Dementia: People who are indifferent are not only more prone to dementia, but their brain structures are very different! For details, please refer to: Alzheimer & Dementia: People who are indifferent are not only more prone to dementia, but their brain structures are very different! Alzheimer & Dementia: Indifferent people are not only more prone to dementia, their brain structures are very different!

3.

3.

GWAS prevention

They used meta-analysis and large-scale GWAS to analyze stroke and stroke-related traits in East Asians.

The results showed that during a total of 367,750 person-years (with an average follow-up of 9.
0 years), 1,227 participants had a stroke before the age of 80
.
Compared with individuals with low polygenic risk, individuals with high polygenic risk are about twice as likely to have a stroke (HR: 1.
99, 95% CI: 1.
66-2.
38), and the lifetime risk of stroke is 25.
2% (95%).
CI: 22.
5%-27.
7%) and 13.
6% (95%CI: 11.
6%-15.
5%)
.
At the same time, individuals with high polygenic risk and family history showed a lifetime risk as high as 41.
1% (95% CI: 31.
4%-49.
5%)
.

Compared with individuals with low polygenic risk, individuals with high polygenic risk are about twice as likely to have a stroke (HR: 1.
99, 95% CI: 1.
66-2.
38), and the lifetime risk of stroke is 25.
2% (95%).
CI: 22.
5%-27.
7%) and 13.
6% (95%CI: 11.
6%-15.
5%)
.
Compared with individuals with low polygenic risk, individuals with high polygenic risk are about twice as likely to have a stroke (HR: 1.
99, 95% CI: 1.
66-2.
38), and the lifetime risk of stroke is 25.
2% (95%).
CI: 22.
5%-27.
7%) and 13.
6% (95%CI: 11.
6%-15.
5%)
.

For details, refer to: Neurology: Academician Gu Dongfeng and Fuwai Hospital found that polygenic risk scores can reflect the prognosis of stroke

Details Reference: Neurology: Gu Dongfeng joint Fu Wai Hospital, Chinese Academy of discovery: polygenic risk score may reflect the prognosis of stroke details Reference: Neurology: Gu Dongfeng joint Fu Wai Hospital, Chinese Academy of discovery: polygenic risk score may reflect the prognosis of stroke Neurology: Dongfeng Gu Academician and Fuwai Hospital found that: polygenic risk score can reflect the prognosis of stroke

4.
Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid

4.
Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid 4.

Recently, American researchers have explored whether the water exchange rate (kw) across the BBB is related to the cerebrospinal fluid (CSF) biomarkers (Aβ42, total tau[t-tau], hyperphosphorylation) of AD pathology in elderly people with normal cognition.
tau[p-tau]) related
.
They performed diffusion preparation, arterial spin labeling (DP-ASL) scans of 40 cognitively normal elderly (67-86 years old), which estimated the water exchange rate (kw) across the BBB
.

Recently, American researchers have explored whether the water exchange rate (kw) across the BBB is related to the cerebrospinal fluid (CSF) biomarkers (Aβ42, total tau[t-tau], hyperphosphorylation) of AD pathology in elderly people with normal cognition.
tau[p-tau]) related
.
They performed diffusion preparation, arterial spin labeling (DP-ASL) scans of 40 cognitively normal elderly (67-86 years old), which estimated the water exchange rate (kw) across the BBB
.

The results showed that in multiple brain regions (whole brain, frontal lobe, precuneus, parietal lobe, temporal lobe, medial temporal lobe), BBB kw and CSF amyloid β (Aβ) 42 concentration levels were positively correlated
.
The low water exchange rate across the BBB is related to the low CSF Aβ42 concentration
.
kw may be a non-invasive index that promotes the clearance of BBB Aβ, and this possibility should be further verified in future studies
.

The results showed that in multiple brain regions (whole brain, frontal lobe, precuneus, parietal lobe, temporal lobe, medial temporal lobe), BBB kw and CSF amyloid β (Aβ) 42 concentration levels were positively correlated
.
BBB kw was positively correlated with CSF amyloid β (Aβ) 42 concentration level
.
The low water exchange rate across the BBB is related to the low CSF Aβ42 concentration
.
kw may be a non-invasive index that promotes the clearance of BBB Aβ, and this possibility should be further verified in future studies
.

For details, please refer to: Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid

Details Reference: Alzheimers Dementia: BBB water exchange rates and cerebrospinal fluid levels of amyloid highly relevant details Reference: Alzheimers Dementia: water exchange rate of the blood brain barrier and cerebrospinal fluid levels of amyloid highly relevant details Reference: Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid Alzheimers Dementia: The water exchange rate of the blood-brain barrier is highly correlated with the level of amyloid in the cerebrospinal fluid

5.
Radiology: Don't use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives in imaging and anatomy

5.
Radiology: Don't use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives in imaging and anatomy 5, 5,5,

Recently, a study published in the journal Radiology used R2* relaxation rate mapping technology to compare the overall and regional iron content of brain tissue between AD patients and age-matched HC patients, and evaluated the 17-month follow-up of AD patients The longitudinal R2* changes during the period and the relationship between iron content data and cognitive decline have been determined, which provides a reference for the clinical further clarification of the mechanism and pathological process of AD, and provides technical support for the early diagnosis and treatment of AD
.

Recently, a study published in the journal Radiology used R2* relaxation rate mapping technology to compare the overall and regional iron content of brain tissue between AD patients and age-matched HC patients, and evaluated the 17-month follow-up of AD patients The longitudinal R2* changes during the period and the relationship between iron content data and cognitive decline have been determined, which provides a reference for the clinical further clarification of the mechanism and pathological process of AD, and provides technical support for the early diagnosis and treatment of AD
.
diagnosis

A total of 100 AD patients (mean age 73±9 years [standard deviation]; 58 women) and 100 age-matched HC participants (mean age 73±9 years; 60 women) were evaluated in the study
.
The results showed that the iron content of deep gray matter and neocortex in Alzheimer's disease patients was higher than that in healthy controls
.
Over time, changes in the iron content of the temporal lobe are related to the cognitive decline of patients with Alzheimer's disease
.
This research is helpful for clinical in-depth understanding of the pathophysiology of Alzheimer's disease, and it also provides new ideas for you to remember one step in related research
.

A total of 100 AD patients (mean age 73±9 years [standard deviation]; 58 women) and 100 age-matched HC participants (mean age 73±9 years; 60 women) were evaluated in the study
.
The results showed that the iron content of deep gray matter and neocortex in Alzheimer's disease patients was higher than that in healthy controls
.
Over time, changes in the iron content of the temporal lobe are related to the cognitive decline of patients with Alzheimer's disease
.
This research is helpful for the in-depth clinical understanding of the pathophysiology of Alzheimer's disease, and it also provides new ideas for the relevant research that remembers one step
.
A total of 100 AD patients (mean age 73±9 years [standard deviation]; 58 women) and 100 age-matched HC participants (mean age 73±9 years; 60 women) were evaluated in the study
.
The results showed that the iron content of deep gray matter and neocortex in Alzheimer's disease patients was higher than that in healthy controls
.
Over time, changes in the iron content of the temporal lobe are related to the cognitive decline of patients with Alzheimer's disease
.
This research is helpful for the in-depth clinical understanding of the pathophysiology of Alzheimer's disease, and it also provides new ideas for the relevant research that remembers one step
.
The iron content of deep gray matter and neocortex in Alzheimer's disease patients is higher than that in healthy controls
.
Over time, changes in the iron content of the temporal lobe are related to the cognitive decline of patients with Alzheimer's disease
.
This research is helpful for the in-depth clinical understanding of the pathophysiology of Alzheimer's disease, and it also provides new ideas for the relevant research that remembers one step
.

For details, please refer to: Radiology: Don't use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives in imaging and anatomy

For details, please refer to: Radiology: Don't use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives on imaging and anatomy.
For details, please refer to: Radiology: Don’t use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives on imaging and anatomy.
For details, please refer to: Radiology: Don't use the old method to evaluate the iron content of the brain tissue of AD patients! New perspectives on imaging and anatomy.
For details, please refer to:Radiology: Don’t use the same old method to evaluate the iron content of the brain tissue of AD patients! New perspectives on imaging and anatomy.
Fordetails, please refer to:Radiology: Don’t use the same old method to evaluate the iron content of the brain tissue of AD patients! A new perspective on imaging and anatomy: Radiology: Don't use the old method to evaluate the iron content of the brain tissue of AD patients! New perspectives in imaging and anatomy

6.
Brain: activation of microglia and permeability of the blood-brain barrier in cerebral small vessel disease

6, Brain: activation of microglia and blood-brain barrier permeability in cerebral small vessel disease 6, 6,6,6,6,

Recently, the Journal of Brain published a research paper, using DCE-MRI data to evaluate the permeability of the blood-brain barrier, and C-PK11195 PET data to evaluate the activation of microglia
.
The study determined whether there is evidence of increased BBB permeability, especially hotspot areas with increased permeability, and the relationship between these and WMH
.
It is further determined whether there are areas with increased microglia activation, and if so, how these areas are spatially related to areas with increased blood-brain barrier permeability
.

Recently, the Journal of Brain published a research paper, using DCE-MRI data to evaluate the permeability of the blood-brain barrier, and C-PK11195 PET data to evaluate the activation of microglia
.
The study determined whether there is evidence of increased BBB permeability, especially hotspot areas with increased permeability, and the relationship between these and WMH
.
It is further determined whether there are areas with increased microglia activation, and if so, how these areas are spatially related to areas with increased blood-brain barrier permeability
.

The results of this study show that in sporadic SVD, the permeability of the blood-brain barrier and the activation of microglia both increase, but they are spatially different
.
It provides further evidence that these processes may represent therapeutic targets for the disease
.
However, the results of this study prove the correlation, rather than causation, and longitudinal and intervention studies are needed to determine whether these processes promote the progression of white matter damage and clinical symptoms
.
The study also proved that different processes may play an important role in CADASIL, and the increase in blood-brain barrier permeability plays a secondary role, but it did find evidence of increased microglia activation areas in single-gene and sporadic SVD .

The results of this study show that in sporadic SVD, the permeability of the blood-brain barrier and the activation of microglia both increase, but they are spatially different
.
It provides further evidence that these processes may represent therapeutic targets for the disease
.
However, the results of this study prove the correlation, rather than causation, and longitudinal and intervention studies are needed to determine whether these processes promote the progression of white matter damage and clinical symptoms
.
The study also proved that different processes may play an important role in CADASIL, and the increase in blood-brain barrier permeability plays a secondary role, but it did find evidence of increased microglia activation areas in single-gene and sporadic SVD .

The results of this study show that in sporadic SVD, the permeability of the blood-brain barrier and the activation of microglia both increase, but they are spatially different
.
It provides further evidence that these processes may represent therapeutic targets for the disease
.
However, the results of this study prove the correlation, rather than causation, and longitudinal and intervention studies are needed to determine whether these processes promote the progression of white matter damage and clinical symptoms
.
The study also proved that different processes may play an important role in CADASIL, and the increase in blood-brain barrier permeability plays a secondary role, but it did find evidence of increased microglia activation areas in single-gene and sporadic SVD .

For details, please refer to: Brain: Microglia activation and blood-brain barrier permeability in cerebral small vessel disease

For details, please refer to: Brain: Microglial cell activation and blood-brain barrier permeability in cerebral small vessel disease.
For details: Brain: Microglia cell activation and blood-brain barrier permeability in cerebral small vessel disease.
Brain: Cerebral small vessel disease microglia activation and blood-brain barrier permeability

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