Progress has been made in the study of the mechanism of regulation of oyster blood lymphatic swallowing.

The Research Team on Marine Biomolecular Biology and Genetics of Marine Biomolecular Biology and Ecology at the South China Sea Marine Research Institute of the Chinese Academy of Sciences has been engaged in the evolution mechanism of natural immunity and has made important recent research progress in the study of the phagocytopharycation control mechanism of oyster blood lymphinal stompation of marine invertebratesSwallowing is one of the oldest and most basic cellular defense mechanisms in living organisms consisting of a series of key events such as pattern recognition on the cell surface, formation and maturation of intracellular phagocytosisHowever, its mechanism and regulation mechanism are not yet clear in marine invertebratesIn order to clarify the molecular mechanism of the oyster engulfing process, the researchers identified the early and late phagocytosis proteins of oyster blood lymphocytes by density gradient centrifugal combination of high-throughput protein quantitative techniques to reveal cytoskeleton remodeling and protein signal regulation to drive the formation and maturation of phagocytosus and confirm the maturity of the endosomenalyscosis involved in phagocytosWhere the signal family members and by controlling the cytoskeleton remodeling affect the maturation and pathogen removal of the phagocytose (figure)The study not only reveals that oyster swallowing is a highly complex and dynamicly regulated process that also provides a basis for in-depth understanding of the evolution of invertebrate swallowingThe paper was published on the subjectOyster's swallowing has evolved over time to demonstrate a unique adaptability to the surrounding environmentThe researchers found that the most abundant anion chloride ions in seawater played a key role in oyster blood lymphatic immunity defensesOyster blood lymphocytes can significantly activate the chlorine ion internal flow during infection or swallowing, while inhibiting the chlorine ion channel, which can significantly block the phagocytosis and sterilization of blood lymphocytesFurther studies have found that the chlorine ion internal flow can activate the signaling pathway to regulate the formation of phage and promote the acidification of the phage and the production of mediated sterilization capacityThrough oyster genome sequence screening, it was found that alpha is the key gene responsible for the internal flow of chloride ions to mediate the immune defense regulation of chloride ion dependenceThe paper was published on the subjectThe above-mentioned study systematically analyzes the molecular regulation mechanism of oyster swallowing and adds to the new dimension of invertebrate immune defense cognition, which lays a good foundation for the study of natural immune molecular evolutionThe work is jointly funded by the National Natural Science Foundation of China, the Guangdong Provincial Laboratory of Marine Science and Engineering in the South China Sea (Guangzhou), the National Shellfish Industry System, the Pearl River Science and Technology New Star in Guangzhou City, and the South China Sea Ecological Environment Engineering Innovation Research Institute of the Chinese Academy of Sciences)