Progress has been made in the study of the mechanism by which central body protein regulates brain development

The neurodevelopment of mammals is a process that is precisely regulated and requires the normal proliferation, differentiation, migration and maturation of nerve prescient cells, which eventually forms the entire neural network.
Talpid3 protein is a protein that is located on a central grain, genetic studies have shown that mutations in the Talpid3 (KIAA0586) gene can cause Joubert syndrome.
Joubert syndrome is a rare and serious neurodevelopmental disorder caused by fibre defects, in which the patient's microcephaly, brain dryness, or dysplas, co-dysfunction and balance disorders occur, but there have been few studies in the academic community on the normal development of the cerebral cortical layer.
Because patients are accompanied by varying degrees of intellectual and cognitive impairment, and the cerebral cortical layer is the functional region responsible for advanced cognition, the question of whether the central protein Talpid3 affects the development of the cerebral cortical layer leading to Joubert syndrome needs to be studied in depth.
the above-mentioned problems, researchers from the Institute of Transmission and Developmental Biology of the Chinese Academy of Sciences conducted research.
researchers used intracranial electrodynrapy in uterine embryos to knock down the Talpid3 protein in the cerebral cortical layer of E13.5-day-old embryonic mice, and found that knocking down Talpid3 during the development of the cerebral cortical layer in mice led to abnormal stratization and radiation in the cerebral cortical layer. The dynamic migration of glial cells (Radial Glial Cells, RGCs) from the base to the top is defective, trapping at the base of the brain chamber region and dividing early into intermediate preciptor cells, ultimately affecting the number of neurons produced in the cerebral cortical layer.
results were validated in Nestin-Cre, Talpid3f/f, and Emx1-Cre;
further study found that Talpid3 regulates the integrity of the central body to maintain the stability of microcontrol tissue, thus maintaining the integrity of the bonding connection at the top of the brain surface, and thus regulating the process of neural stem cell proliferation and differentiation.
the study revealed a new mechanism by which central proteins affect the development of the cerebral cortical layer by regulating bonding connections.
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