Progress has been made in the study of "magnetic knife" inhibition of tumor growth.

Recently, Wang Hui and Zhang Xin, researchers of the strong magnetic field science center of Hefei Institute of material sciences, Chinese Academy of Sciences, synthesized bile like nickel nanoparticles (unnps) by magnetic solvothermal method to achieve tumor cell apoptosis and tumor growth inhibition induced by rotating magnetic field.the related research results were published in the chemical engineering journal with the title of synthesis of urchin like nickel nanoparticles with enhanced rotating magnetic field induced cell neurosis and tumor involvement.in recent years, magnetic nanoparticles (MNPs) have been used in cancer treatment, and the concept of "magnetic scalpel" has been proposed, that is, under the action of rotating magnetic field, magnetic nanoparticles produce mechanical force with the function of "rotating stirring", which can destroy tumor cells and achieve the same effect as the scalpel.this kind of "magnetic knife" composed of magnetic nanoparticles is not a traditional "knife", it is a kind of "mechanical force" driven by magnetic field. This force is similar to the turbine force produced by a juicer when mixing fruit. The fruit is crushed under the action of the turbine force, and the cells are crushed under the mechanical force of magnetic field until death.because of its advantages of deep-seated tumor treatment and remote manipulation, magnetomechanical cancer therapy has attracted continuous attention in this field.at present, different types of MNPs have been used in the treatment of cancer induced by magnetic machinery. However, these MNPs have the disadvantages of smooth surface and weak magnetism, so it is difficult to make further progress in the treatment of magnetomechanical cancer.therefore, it is of great significance to design a kind of MNPs with high saturation magnetization and structure specificity for improving the treatment efficiency of magnetic mechanical cancer.researchers have synthesized unrps in one step by using external magnetic field and solvothermal method. The related characterization and experiments show that the unnps have the advantages of high saturation magnetization and structural specificity, and have no obvious toxic and side effects on normal cells and organisms.under low frequency rotating magnetic field, unnps showed the effect of "magnetic knife", which effectively inhibited the growth of breast cancer in mice.the research work was supported by the National Natural Science Foundation of China, the start-up fund of Hefei Research Institute, the president fund of Hefei Research Institute, the collaborative innovation and cultivation fund of Hefei University Science Center, and the Key Laboratory of medical physics technology of Anhui Province.the mechanism of mechanical force induced by rotating magnetic field to inhibit tumor growth source: Hefei Institute of material science, Chinese Academy of Sciences