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Professor Yin Yuxin: A new mechanism for the anti-cancer gene PTEN family member PTENɑ to promote tumor immune escape

 Last Update: 2021-09-13
 Source: Internet
 Author: User

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On August 26, 2021, the team of Professor Yin Yuxin from the Institute of Systems Biomedicine of Peking University and the Joint Center for Life Sciences published an online publication titled "PTENɑ functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer" in Nature Communications.
The research paper, for the first time, described the molecular mechanism of PTENɑ, a member of the PTEN family, that promotes tumor immune escape by reducing the sensitivity of tumor cells to host immune attacks
.

The anti-cancer gene PTEN has high frequency mutations in many tumors

In summary, as an important immunosuppressive factor, phosphatase PTENα can limit the host's immune surveillance function and promote tumor immune escape
.

The specific targeting of the PTENα pathway can increase the sensitivity of tumor cells to immune killing

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