Professor Xiao Jie of the College of Food Science of South China Agricultural University has published a series of research results in TOP journals in the field

Recently, Professor Xiao Jie of the College of Food Science of South China Agricultural University (deputy director of Guangdong Provincial Key Laboratory of Active Functional Foods and leader of Guangdong Province Steady-state Efficiency Delivery Technology Innovation Research Team) as the corresponding author on the principles and technologies of the steady-state and synergistic delivery system of food functional factors in the Journal of co ntrolled release (IF 11.
467; JCR Region 1 TOP) published the important research paper "Intervention effects of multilayer core-shell particles on colitis amelioration mechanisms of.
" capsaicinhttps://doi.
org/10.
1016/j.
jconrel.
2022.
09.
041”
。 Previously, he published a Critical Reviews in Food Science and Nutrition (IF 12.
258; JCR Region 1 TOP) "Updated design strategies of functio" as the first/corresponding author of this research direction nal delivery systems for achieving maximized bioefficacy of dietary bioactive compounds.
https://doi.
org/10.
1080/10408398.
2022.
2109583", and a Journal of co ntrolled release (IF 11.
467; JCR Region 1 TOP)"Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis.
https://doi.
org/10.
1016/j.
jconrel.
2022.
06.
058”
。

 

（1）《Updated design strategies for oral delivery systems: maximized bioefficacy of dietary bioactive compounds achieved by inducing proper digestive fate and sensory attributes.
》Crit.
Rev.
Food Sci.
Nutri.
DOI: 10.
1080/10408398.
2022.
2109583.
First and corresponding author: Xiao Jie

 

The maximization of the health effect of food functional actives and the relationship between biological fate and health mechanism are the research focus and difficulties in the field of functional foods
.
In this paper, the guiding idea of functional delivery system upgrade design is proposed: precise directional delivery to achieve sensory upgrading of functional factors oral flavor and maximize
biological efficacy 。 The key points of emerging design strategies for functional delivery systems are proposed: the distribution ratio and biological fate of regulatory functional factors (1) between the upper and lower gastrointestinal tracts; (2) mucosal adhesion-osmotic transport efficiency and its digestion time lag at target site; (3) portal vein and lymphatic absorption ratio; (3) the proportion of absorption and metabolism mediated by human digestive enzymes (direct) and intestinal flora enzymes (indirectly); (5) Upgrading of oral sensory and flavor perception characteristics; (6) Synergistic effect
with matrix materials or co-delivery of multiple functional factors.
In addition to improving bioavailability, it provides innovative ideas
for functional delivery systems to improve the digestion and metabolic balance between the residence time of food functional factors at the target absorption site, host bioavailability and microbial metabolism, and trigger the beneficial metabolism and required sensory properties of functional factors in the digestive tract, so as to maximize the biological efficacy of functional factors.

 

(2) "Intervention effects of delivery vehicles on the therapeutic efficacy of 6-gingerol on colitis" first author: Tian Wenni (doctoral candidate), corresponding author: Xiao Jie

 

In view of the scientific concept of "the proportion of regulatory functional factors in the absorption and metabolism mediated by host digestive enzymes or intestinal flora enzymes, so that the active substances can be reasonably absorbed on targets with suitable biological fate, so that they can exert the maximum biological effect", this paper studies the intelligent structure design of the delivery system, constructs an oral delivery system with upper/lower gastrointestinal targeted absorption enhancement to achieve precise and flexible regulation of the digestive fate and biodistribution of functional actives.
Furthermore, the regulation of the health effects and mechanisms of functional active substances by host digestive enzymes and intestinal microbiota enzyme-mediated digestion, absorption and metabolism pathways on the functional active substances was revealed.

 

It was found that the nanostructure lipid carrier (NLC), a targeted delivery vehicle for the upper gastrointestinal tract, realized the slow release and accumulation of 6-gingerol in the small intestine, while the targeted delivery vehicle for the lower digestive tract, multilayer microcapsules, achieved the specific release and time-delay enhancement effect
of 6-gingerol in the colorectal site 。 After the absorption and metabolism mediated by the upper gastrointestinal host digestive enzyme system, 6-gingerol alleviates DSS-induced colitis by regulating the antioxidant/anti-inflammatory pathway and the ratio of Firmicutes/Bacteroides, while 6-gingerol targets the site of colonic inflammation to significantly enhance the two-way communication between 6-gingerol and intestinal flora, and triggers a new "TRPV1-mucus-intestinal flora cycle" cascade inflammatory relief mechanism
.

 

(3) "Intervention effects of multilayer core-shell particles on colitis amelioration mechanisms of capsaicin" first author: Wang Haonan (master student), corresponding author: Xiao Jie

 

In this research work, oral synergistic delivery systems with different hierarchical structure and release characteristics (respectively: core-shell nanoparticles Cap NPs, core-shell microparticles Cap MPs, and core-shell nano-in-micron particles Cap NPs in MPs)
were constructed using the same materials.
In terms of colitis relief mechanisms, Cap NPs, which are mainly absorbed in the small intestine, are significantly different
from Cap MPs and Cap NPs in MPs, which are mainly colonic accumulation.
Cap NPs mainly relieve colitis by promoting the colonization of short-chain fatty acid-producing bacteria, maintaining intestinal barrier homeostasis and partially inhibiting
the activation of the NF-κB inflammatory pathway.
However, by promoting the proliferation of muco-related bacteria and improving the trigger efficiency of the "TRPV1-mux-microbiota cycle" cascade, Cap NPs in MPs have achieved better dietary intervention effects
.
It is proved that the controlled delivery system can regulate the distribution sites and release efficiency of functional factors in the body, so that functional factors can be reasonably absorbed on targets with suitable biological fate, so as to maximize their biological effects
.

 

The above series of studies provide innovative ideas for the regulation of the precise health mechanism of digestion and absorption sites and degrees mediated by functional delivery systems and the interaction process of intestinal flora, and reveal the important instrumental value
of upper and lower gastrointestinal directed absorption enhanced delivery systems as multi-dimensional regulation of functional factor health effects.
The supporting platforms for the above research results are: Guangdong Provincial Key Laboratory of Active Substances in Functional Foods and Guangdong Province Steady-State Efficiency Delivery Technology Innovation Research Team
for Functional Foods.

 

Vingram/Food Academy