Professor Chengchao Shou’s team reveals the anti-angiogenesis effect and mechanism of Aiphanol, an extract of Smilax glabra

2021 Nian 12 Yue 3 days, Peking University Cancer Hospital life into a super team of professors in Signal Transduction and Targeted Therapy published "online entitled Aiphanol, the Compound A Native, suppresses angiogenesis Via Dual-Targeting VEGFR2 and COX2 " research paper, describes the earth Aiphanol, an extract of Poria cocos, antagonizes the mechanism of angiogenesis through the dual targets of VEGFR2 and COX2 , laying an important foundation for the subsequent development of new anti-tumor drugs

The use of Chinese medicine / natural medicine has been the main method used by humans to treat various diseases for thousands of years, and the effective ingredients or components contained therein have great potential that can be continuously tapped

Smilax glabra is a commonly used traditional Chinese medicine.

In addition to directly inhibiting tumor cell growth and metastasis, Professor Shou Chengchao's team also found that Smilax glabra extract has a significant anti-angiogenic effect

Through further cooperation with Professor Cai Shaoqing’s research group from the School of Pharmacy of Peking University, Professor Chengchao Shou’s team separated a series of monomer compounds from the components of the ethyl acetate extract of Smilax glabra, including those that have been reported to have anti-angiogenic activity.

Around Aiphanol extract component was whether the anti-tumor activity of this issue in Smilax ethyl acetate, professor of life into a super team to be more systematic study found Aiphanol a variety of in vitro and in vivo anti-angiogenic models are displayed A significant anti-angiogenesis effect

Doctoral student Chen Shanmei is the first author of the paper

Article link: https:// lang="EN-US" > (Peking University Cancer Hospital)