Probiotic lyophilization process development How to choose a laboratory lyophilizer

Under the background of great health and people's consumption upgrading, the market size of China's probiotic industry is expected to exceed the scale
of 100 billion.

In order to better develop probiotics to occupy the market, domestic and foreign probiotic enterprises should increase scientific research investment, develop more strains with independent intellectual property rights, probiotic lyophilizer is a must use vacuum freeze-drying equipment, how to choose a laboratory lyophilizer when the lyophilization process research and development of biotics is a problem
for some enterprises.

Probiotics are beneficial active microorganisms, with the effect of regulating the host mucosa and systemic immune function or by regulating the balance of the intestinal flora, promoting nutrient absorption and maintaining intestinal health, mainly yeast, probiotic spores, Clostridium butyrate, Lactobacillus, Bifidobacterium, Actinomycetes and other varieties
.

Most probiotics need to survive in a specific environment, are very heat-sensitive active substances, are susceptible to temperature, and have a particularly short
shelf life.

In order to enhance the stability of probiotics need to be dried by probiotic lyophilizer for low-temperature vacuum sublimation drying, lyophilization process is very critical in lyophilization processing, it is necessary to ensure that the production of probiotic lyophilized powder retains more than 95% of the active substances, has instant solubility, can be stored at room temperature for a long time and other requirements
.

Therefore, the research and development of probiotic lyophilization process needs to correctly select the laboratory lyophilizer, among which the probiotic laboratory lyophilizer needs to meet the research and development of lyophilization process data to ensure that the lyophilization process of a large number of probiotic lyophilization production in the later period has been reshaped
.

According to the requirements of probiotic experimental research and development requirements, probiotic freeze dryers need to choose equipment with the following technical requirements: 1) use contact lyophilizers; 2) Partition valve between the front and rear boxes; 3) Partition temperature control range: -60 ~ 70 °C; 4) Condensation limit temperature: -80°C; 5) Ultimate vacuum: 1PA; 6) Box, partition, material, condenser material: 304 or 316 stainless steel; 7) Unit accessories: choose imported brands; 8) Has the function: (1) lyophilization process data setting, modification; (2) Recording, storage and traceability of lyophilized data and curves; (3) It has the function of cooling rate and heating rate control; (4) With vacuum fine adjustment function; (5) Online pressure rise test function; (6) Online eutectic point test; (7) Permission management and password management functions; (8) Remote operation and monitoring function
.