Preparation of decolorizing and whitening drugs

2013-07-27 classification: efficacy, function, plant extraction industry trends (I) arbutin whitening cream formula: arbutin; stearic acid 5.0g; octadecyl alcohol 4.0g; butyl stearate 8.0g; monoglyceride 2.0g; propylene glycol 10.0g; potassium hydroxide 0.2g; water added to 100.0g Efficacy: whitening and inhibiting tyrosinase, used for chloasma and various color spots （2） Prescription of compound kojic acid cream: crystal 2.0g; vitamin e1.0g; verniline 5.0g; cetyl alcohol 8.0g; monoglyceride 4.0g; bht1.0g; liquid paraffin 4.0g; spar 80, 2.0g; titanium dioxide 5.0g; polyethylene glycol 4.0g; sodium dodecyl sulfate 1.0g; refined water added to 1000.0g Efficacy: nourish skin to inhibit tyrosinase and sunscreen, and be used for chloasma, sunburn, and color deposition after grinding （3） Prescription of compound hydroquinone ester cream: 2.5G hydroquinone ester; 0.1g vitamin ester; 0.9g vitamin e1.0 from Scutellaria extract; 5.0g octadecyl alcohol 9.0 from monoglyceride; 5.0g liquid paraffin; 3.0g bhtl.0 from titanium dioxide; 5.0g glycerin; 1.0g sodium dodecyl sulfate; add purified water to 100.0g Efficacy: it has the functions of sunscreen, tyrosinase inhibition, skin nutrition, etc it is suitable for freckles, chloasmas and various facial color sinks （4） Prescription of compound hydrogen ester cream: hydroquinone 3.0g; tretinoin 0.1g; dexamethasone 0.1g; white vaseline 8.0g; octadecyl alcohol 8.0g; monoglyceride 4.0g; bht1.0g; Span 80, 2.0g; liquid paraffin 4.0, polyethylene glycol 400, 4.0g; glycerin 5.0g; sodium dodecyl sulfate 1.0g; deionized water added to 100.0g Efficacy: it is suitable for freckles, chloasma and all kinds of facial color （5） Prescription of nonwei anti spot cream: 10.0g nonyldiacid; 1.0g vitamin; 25.0g propylene stearate; 3.0g gelatin; 2.0g triethanolamine; bht1.0g; Tween 80, 1.0g; glycerin 7.0g; sodium dodecyl sulfate 0.5g; refined water added to 100.0g Efficacy: nourish skin, inhibit tyrosinase, apply to chloasma and various facial complexion （6） Prescription of compound palmitate ascorbic acid cream: 2.0g palmitate, 0.1g vitamin e1.0 retinoic acid, 15.0g octadecanol, 5.0g monoglyceride, 5.0g liquid paraffin, 5.0g glycerin, 1.0g sodium dodecyl sulfate, 5.0g urea, 1.0g azone, and 100.0g purified water Efficacy: nourish skin, inhibit tyrosinase, apply to chloasma and all kinds of colors, whiten and sunscreen （7） Prescription of Huoxue Xiaoban whitening cream: Panax notoginseng extract 1.0g; safflower extract 0.5g; pearl powder 1.0g; placenta extract 0.5g; octadecyl alcohol 10.0g; monoglyceride 5 Er; liquid paraffin 5.0g; glycerin 5.0g; sodium dodecyl sulfate 1.0g; proper amount of antiseptic, antioxidant and aromatic agent; refined water added to 100.0g Efficacy: nourish, activate blood, whiten, apply on the face late to treat chloasma and various color spots, whiten （8） The formula of hydroquinone cream: 30g hydroquinone, 75g stearic acid, 50g white vaseline, 50g monostearate, 125g liquid paraffin, 2G dodecyl sodium sulfate, 10g triethanolamine, 100g glycerin, LG Nipagin ethyl ester, 2.6-tert-butyl-p-cresol (BHT) 2.5 distilled water 541.5ml to make 1000g Preparation: take the oil phase to form stearic acid and white vaseline Glycerin monostearate and liquid paraffin are put into water bath, heated to 70-8012, added to BHT for dissolution; in addition, sodium lauryl sulfate, triethanolamine, ethyl nipagine, anhydrous sodium sulfite and disodium ethylenediaminetetraacetate are taken for dissolution in distilled water, and heated to 70-80 ℃, when the two temperatures are the same, the oil phase is slowly added to the water phase, when stirring to 70-8012, the hydrogen ester and glycerin are ground and added Put in and stir until it condenses Function and application: skin decolorizer, used for pigmented skin diseases, such as chloasma, freckle, melanosis and pigmentation after inflammation Usage and dosage: apply to the affected area at night Storage: dark and airtight matters needing attention: (1) The pharmacological action of hydroquinone is to block the process of tyrosinase catalyzing the conversion of tyrosine to dihydroxyphenylalanine, so as to control the biosynthesis of melanin, but it does not damage the melanocytes, nor affect the synthesized melanin (2) Hydroquinone is hydroquinone, which is very easy to oxidize Especially in alkaline condition, it can be quickly oxidized to quinone structure, brown or even black Therefore, the following aspects should be paid attention to in the formulation design, preparation and storage of this product: ① This product should be added with a variety of antioxidants: water-soluble antioxidants such as anhydrous sodium sulfite, sodium thiosulfate, vitamin C, oil soluble antioxidants such as BHT (2.6 tert butyl p-cresol, tert butyl p-hydroxyanisole), chelating agents such as disodium ethylenediamine tetraacetate (edta-2na), etc ② When hydroquinone is added into emulsion, the temperature should not be too high ③ Avoid metal containers and use a bamboo ointment knife Storage should be kept away from light in glass bottles or colored plastic bottles with rotating lids (nine) Angelica freckle cream formula: stearic acid 10g; glycerol monostearate 1.0g; eighteen alcohol 2G; glycerol 5g; borax 0, 5g; menthol 0.; Angelica dahurica extract 1.5g; Angelica Extract 1.5, preservative 0.2g; antioxidant 0.15g; distilled water 77.5g essence.