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Prof.
Predicting the future may be out of our grasp, but what about predicting disease progression? Researchers in Japan have delved into the human genome to investigate a predictive tool for rheumatoid arthritis (RA) progression
In a new study published in the journal Arthritis and Rheumatology, researchers led by Tokyo Medical and Dental University (TMDU) used data from a genome-wide association study (GWAS) of RA susceptibility to construct Polygenic Risk Score (PRS)
In GWAS, genome analysis is performed on a group of individuals to identify genetic variants that may be associated with a trait or disease
"We generated the PRS using summary statistics from the RA susceptibility analysis at GWAS and retrospectively assessed joint damage on radiographs from patient medical records," explains first author Suguru Honda
The researchers then performed a statistical analysis to assess whether there was an association between PRS and the severity of radiographic progression
"Our analysis revealed a link between PRS and radiological progression," said senior author Yuta Kochi
The researchers found that patients with higher PRS levels had a higher risk of severe progression, especially in younger patients
