Pre-filled injection pen to administer a key point ignored by domestic pharmaceutical companies.

The current ways of administration are varied, and the common routes of administration are subcutaneous injection, intravenous injection, oral, smearanding and so on. there is a strong link between the way
is administered and the therapeutic effect.
the same drug, because of the different ways of administration, its efficacy is also very different.
this paper only for the formulation of the way to administer, through the case of foreign pharmaceutical enterprises to use the written test syringe, analysis of its advantages of the way to administer, as well as the domestic pharmaceutical enterprises to give the way to choose the thinking.
several foreign drugs including adamusin, ethane, alisiumonosa, monoclonal antibody drugs, and even PD-1, PD-L1, epinephrine and many other heavy drugs are used in the pre-filled injection pen of the drug.
Case 1: Abbott's Humira, admu monoanti-.
Abbott's Humira, which includes up to 12 types of rheumatoid arthritis, hypertheritis, psoriasis, and has sales of $19.9 billion in 2019.
the way this drug is administered for subcutaneous injections, the choice of dosing devices is the injection pen, pictured as follows: Case 2: Merck's Imraldi, a generic version of Abbott's Humira, is also given underthecution, the same method of injection pen-to-drug.
Case 3: Novartis's Bydureon, or essenapeptide, a long-acting insulin used to improve blood sugar in patients with type 2 diabetes, is also administered with a pen.
Case 4: Sanofi's Praluent, or Alisiumono, PCSK9 inhibitors, also use subcutaneous injections, as well as injection pens.
Case 5: Regenerative Dupixent, a monoclonal antibody drug that targets IL-4R, is used in immuno-related inflammatory diseases, the same is done with subcutaneous injections, as well as by injecting pens.
the advantages of the injection pen to administer 1, increase the safety of the drug 1.1 dose control precision, and the injection depth and drug propulsion speed are controlled by the mechanism to ensure accuracy.
1.2 The needle is hidden before injection and the needle protection mechanism is self-locking after injection to avoid cross-infection or secondary injury throughout the process.
2, easy to operate, save time and cost 2.1 usually injection pen administration, both in 2 or 3 steps can be completed.
2.2 Administering by Pen, patients can self-inject at home or in the office due to the ease, convenience and reliability of administration, greatly reducing costs and time.
survey data show that the patient's time to complete the injection can be reduced from 65 minutes to 2 minutes.
2.3 Even if a patient goes to hospital, it can still greatly reduce the pressure on hospitals and nurses, reduce errors and reduce workload.
according to the survey data, the nurse's operating time can be reduced from 5 minutes to 2 minutes.
3, increase compliance, reduce injection fear 3.1 For patients, the entire injection process needles are not visible, and simple and convenient operation, can greatly enhance confidence, improve compliance with the drug.
3.2 For pharmaceutical companies, it will increase the brand's influence and identity, helping to differentiate itfrom the white-hot competition.
the development of domestic drug delivery equipment at present domestic pharmaceutical companies have begun to pay attention to the injection pen this way of administration, but because of the domestic injection pen research and development, engineering and production and manufacturing there are short boards: 1, domestic pharmaceutical companies and foreign pharmaceutical companies compared, usually the volume is small, resulting in a small number of injection pen orders.
2, domestic pharmaceutical companies and foreign pharmaceutical companies compared, in the past years, we are mainly generic drugs, one into the market that is white heat, the degree of attention to research and development and innovation is not enough, the attention to the way of administration is naturally small.
3, domestic injection pen research and development and production enterprises are very few, the regulations, systems, patents and product standards are not familiar with, and therefore lack of corresponding talent, Ningbo Reno ElectronicTechnologco Co., Ltd. Hou Shishuang General Manager said that for 15 years, they can only train their own personnel including research and development, quality, production, testing, regulations and other positions to meet the needs of foreign pharmaceutical enterprises.
believe that with the development of domestic pharmaceutical companies, especially the maturity of biotechnology, the injection pen this advanced drug delivery equipment in China will have great progress, look forward to the new advanced mode of drug delivery to pharmaceutical companies, hospitals and medical staff, patients to bring reliable safety convenience and more value.
the author in the writing of this method of administration analysis, noted that Novartis's Cosentyx, that is, Sujin Singanti in the Chinese market began to put into the new Cosentyx, the use of injection pen to administer the method, to keep the price unchanged.
hope that our Chinese pharmaceutical companies can focus on the way to do drugs, improve safety, improve patient compliance, improve the added value of products at the same time, from the competition.
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