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Potential first-in-class inhibitors targeting newly synthesized lethal targets will enter the clinic

 Last Update: 2022-01-12
 Source: Internet
 Author: User

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On November 17, 2021, Mirati Therapeutics announced that it has submitted an IND application for a Phase 1/2 clinical trial to the US FDA to evaluate the PRMT5 inhibitor MRTX1719 for the treatment of methylthioadenosine phosphorylase (MTAP) deficiency The efficacy and safety of cancer

Previous preclinical studies have proven that MRTX1719 is a potent and selective inhibitor of the PRMT5/methylthioadenosine (MTA) complex

The Phase 1/2 trial will determine the dose for the Phase 2 clinical trial and evaluate the safety, pharmacokinetics and initial clinical activity of MRTX1719 in the treatment of MTAP-deficient cancer patients

Reference materials:

[1] Mirati Therapeutics Announces Submission of Investigational New Drug Application to US Food and Drug Administration of MRTX1719 to Treat MTAP-Deleted Cancers.

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