Potential anti-epileptic drug market, Top 5 varieties account for over 80%!

In recent years, under the influence of rising population, genetic factors and environmental factors, the number of patients with epilepsy has continued to increase, and the demand for antiepileptic drug preparations has increased
.

According to data from Minet.
com, the sales of [anti-epilepsy drugs]in public hospitals in key provinces and cities in China will be 1.
327 billion yuan in 2020, and the sales scale is expected to exceed 6 billion yuan if expanded nationwide
.

[Anti-epileptic drugs] are expected to exceed 6 billion yuan
.

(Source: Mine Database)

Epilepsy is a chronic disease in which the central nervous system suffers sudden, repeated or transient loss of function due to excessive discharge of nerves in the brain
.

Loss of consciousness during a seizure can lead to many serious accidents

epilepsy

The purpose of clinical medication is to control symptoms and reduce the number of seizures, thereby reducing the serious consequences of epilepsy
.

At present, the top 5 antiepileptic drugs soldin domestic hospitals are sodium valproate, levetiracetam, oxcarbazepine, lamotrigine, and topiramate, accounting for 86.
7% of the market for such drugs, with obvious head effects
.

The top 5 anti-epileptic drugs in sales accounted for 86.
7% of the drug market, and the head effect was obvious
.

(Source: Mine Database)

Sodium Valproate:

Sodium Valproate:

Acting on GABAA receptors and NMDA receptors, it is suitable for almost all types of epilepsy and seizures.
It is one of the most effective broad-spectrum antiepileptic drugs, so its market share has been high
.

In 2020, the sales of public hospitals in key cities will be 513 million yuan, with injections as the main dosage form (accounting for 70% of the share), Sanofi (65.
2%) and generic drugs Shenyang Xinma Pharmaceutical (21.
5%), Sichuan Keruid (10.
9%) ) occupy the main top three markets
.

513 million yuan,

(Source: Mine Database)

As a broad-spectrum antiepileptic drug, the efficacy of sodium valproate for limited-onset epilepsy is weaker than that of other new antiepileptic drugs
.

Levetiracetam:

Levetiracetam:

It is the only anti-epileptic drug that has been reviewed before the first batch of national procurement declarations
.

Compared with sodium valproate, levetiracetam can control epileptic seizures more effectively, has less side effects such as respiratory, circulatory depression, and organ damage, and has good tolerance and reliable efficacy

The only review before the application

In 2020, the sales of public hospitals in key cities reached 312 million yuan, and tablets were the main dosage form (accounting for 86%)
.

With the over-evaluation of generic drugs and the prominence of the advantages of national procurement, the market share of Jingxin Pharmaceutical and Kangyu Pharmaceutical has expanded to 32.

(Source: Mine Database)

Although levetiracetam is reliable, patients who use the drug have poorer recovery at hospital discharge and a higher rate of seizure recurrence than traditional drugs
.

Oxcarbazepine:

Oxcarbazepine:

It is a new generation of antiepileptic drugs, which can block the voltage-dependent sodium ion channels and potassium ion channels in epilepsy patients, inhibit the repeated nerve discharge phenomenon and synaptic excitation transmission in the body, and reduce the number of epileptic seizures.
It can be used alone , which can also be used as adjuvant therapy, is the first-line drug of choice for adults with newly diagnosed epilepsy, especially those with untreated focal epilepsy
.

first-line drugs

In 2020, public hospitals in key cities will sell 192 million yuan.
Tablets are the main dosage form (88%), and nearly the entire market is occupied by Novartis (92.
5%), Beijing Sihuan (4.
6%), and Wuhan Renfu (2.
9%)
.

(Source: Mine Database)

The incidence of severe and symptomatic hyponatremia after taking oxcarbazepine was 11.
1% and 6.
8%, respectively
.

Lamotrigine:

Lamotrigine:

It is a relatively new broad-spectrum antiepileptic drug and is a powerful antiepileptic drug.
Its action link is to inhibit the release of the excitatory amino acid glutamate from the presynaptic membrane.
The mechanism of action is to inhibit the opening of sodium channels and stabilize the hyperexcited Nerve cell membrane, also has brain protection effect, no self-induction effect in clinical use
.

In 2020, the sales of the sample city hospitals were 91.

(Source: Mine Database)

The most important advantage of lamotrigine is in the maintenance treatment of bipolar disorder , which can significantly prolong the time interval between episodes of mood events, especially new depressive episodes
.

Maintenance therapy for bipolar disorder

Topiramate:

Topiramate:

It is a new type of broad-spectrum antiepileptic drug with unique multiple mechanisms of action, rapid and complete absorption after oral administration, linear pharmacokinetics, high bioavailability, long plasma half-life, good tolerance and safety, domestic It has been widely used in clinical practice
.

This product has been recommended as the preferred anti-epileptic drug by the 2018 American AAN/AES", "2013 International League Against Epilepsy ILAE" and other guidelines

According to Minet.
com, in 2020, the sales revenue of the domestic sample hospital [Topiramate] is 46.
15 million yuan, and the ratio of tablets to capsules is about 8:2.
The product market is temporarily dominated by the original researcher, Xi'an Janssen
.

(Source: Mine Database)

Topiramate is safer and more effective for the treatment of essential tremor , and has less adverse reactions, so it can be the first choice for essential tremor
.

Essential tremor treatment

In the past ten years, with the launch of new anti-epileptic drugs and the expiration of some drug patents, the anti-epileptic drug market has shown ups and downs
.

According to the "Guidelines for the Diagnosis and Treatment of Epilepsy in China": Epilepsy is the oldest and most typical disease in the human central nervous system, with complex etiology, sudden and capricious seizures, and difficult to cure.
It is regarded as a cancer of the nervous system and is called the world's Three ills
.

Moreover, there are large differences in medication, and some drugs are not effective in different patients, so epilepsy is known as a chronic disease

"Guidelines for Diagnosis and Treatment of Anti-epilepsy in China":

A variety of drugs previously marketed abroad are no longer produced, imported and used in China due to their large toxic side effects or restricted by black boxes, such as ezogabine, aminohexenoic acid, felbamate, trimethyldione, ethphenytoin, methylphenidate succinamide, etc.
, the sales performance plummeted in an instant
.

In comparison, the Top 5 (sodium valproate, levetiracetam, oxcarbazepine, lamotrigine, topiramate) that can stand in this field are undoubtedly products with great potential and outstanding efficacy
.

What kind of wonderful performance they will bring in the follow-up, we will wait and see!

Top 5