Poria acid can inhibit acute rejection

Poria acid, the extract of Poria cocos, has the pharmacological effect of inhibiting acute rejection The research led by Liu Hongyu, director of Cardiology Department of the First Affiliated Hospital of Harbin Medical University suggests that Poria acid can effectively reduce the intensity of acute rejection after heart transplantation in experimental animals, significantly prolong the survival time of transplanted heart and reduce the pathological damage This research recently won the second prize of 2011 Heilongjiang Provincial Science and technology progress award Poria cocos is classified as the medicine of seeping water and dampness in traditional Chinese medicine, which has a good effect on abortion, infertility and pregnancy induced hypertension syndrome caused by immune factors Experts speculate that there may be immunosuppressive or tolerance inducing drug components in Poria cocos Under the support of National Natural Science Foundation and science and technology funds of Heilongjiang Provincial Department of education, Liu Hongyu and others first established the rat model of heterotopic heart transplantation The experimental animals were divided into four dose groups for gavage treatment with two concentrations of fulvic acid olive oil mixture every day, and the control group was set up for observation and comparison The results showed that the secretion of IL-2 and ifn-γ in the peripheral blood of the experimental animals could be reduced by the large and small doses of Poria acid, while the effect of the large dose (10mg / kg / day) was more obvious The results showed that pachymanic acid could inhibit the secretion of these two substances and reduce the cytotoxic T cell killing and cardiomyocyte apoptosis In other words, Poria acid can effectively inhibit the acute rejection after organ transplantation, ensure the transplanted heart not to be "disturbed" and "excluded"; at the same time, it can protect the peripheral blood lymphocytes, reduce the percentage of apoptosis, and relatively stabilize the percentage of CD8 + number of peripheral blood lymphocyte subsets.