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Malaria remains a major global health threat.
Malaria remains a major global health threat.
The pathogen of malaria is a single-celled parasite that invades and replicates in red blood cells.
If the parasite can be effectively trapped in the cell by blocking the parasite's exit pathway, it may be possible to prevent the spread of the disease during its course and stop the destructive cycle of its invasion of cells.
Recently , in a study published in PNAS , scientists have developed a set of compounds that can directly inhibit the activity of SUB1 to prevent parasites from erupting from red blood cells and from proliferating.
d org/10.
d org/10.
The compound works by blocking an enzyme called SUB1, which is essential for the outbreak of malaria from red blood cells.
Develop rationally designed peptide PfSUB1 inhibitors.
Develop rationally designed peptide PfSUB1 inhibitors.
Peptide boric acid PfSUB1 inhibitor prevents the escape of Plasmodium falciparum
Importantly, the compound can also pass through the membranes of red blood cells and the intracellular compartments where the parasites are located.
Importantly, the compound can also pass through the membranes of red blood cells and the intracellular compartments where the parasites are located.
The schematic diagram shows that the inhibitor of SUB1 needs to pass through at least two to four layers of membrane to enter and inactivate the parasite in the red blood cell.
The schematic diagram shows that the inhibitor of SUB1 needs to pass through at least two to four layers of membrane to enter and inactivate the parasite in the red blood cell.
The team is continuing to optimize the compound to make it smaller and more effective.
Chrislaine Withers-Martinez, author and researcher at the Malaria Biochemistry Laboratory, said: “Many existing antimalarials are plant-derived.
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