PNAS: Reveals the causes of SARS-CoV-2 high infectiousness and concealment!

2020 May 13 News /BioValleyBIOON / - lead COVID-19 SARS-CoV-2 virus is highly contagiousThe strange thing is, in many patients, it can cause a poor immune response, thereby extending the time of the diseaseThis helps the virus is widespread, exacerbated by the global pandemicIn a new study published in the journal ProceedingsoftheNationalAcademyofSciences, the University of Minnesota researchers have discovered a biochemical mechanism that might explain how the virus to evade the immune response while effectively infect humansSource: PNASThe study by the College of Veterinary Medicine, led by Professor FangLi, studied the SARS-CoV-2 mechanism to enter cellsSpecifically, the researchers studied how the virus surface protein thrusting as a "key" to "unlock" human cellsThey have three important discoveries:o key tip virus closely with human cells; O tip of a virus often hidden key; O time when generating a new virus particles, virus key human enzyme that has been pre-activated"Normally, when a virus develops mechanisms to evade the immune response, it loses its ability to infect humans," Professor Li saidHowever, SARS-CoV-2 to maintain its infectivity by two mechanismsFirst, in the limited exposure time, the tip of the virus will be key for fast and stable seize receptor proteins on human cellsSecond, pre-activation key of the virus so that the virus can infect human cells more efficiently"
Professor Lee said, recognized the concealment is very important to design antibody drugs and vaccines SARS-CoV-2's Antibody drug need to firmly grasp the hidden key to the tip of the virus very quickly in a limited time exposure thus subdue it in addition, the drug can also be crucial for the rest of the virus, these parts more easily exposed Professor Li suggested that the success of antiviral strategies need to consider the effectiveness of the virus and its concealment (biological Valley Bioon.com) references: UncoveringthepotencyandevasivenessoftheCOVID-19virus JianShangetal CellentrymechanismsofSARS-CoV-2, ProceedingsoftheNationalAcademyofSciences (2020) .DOI: 10.1073 / pnas 2003138117