PNAS: Proper Stress, Good for Health!

As the pace of life accelerates, people's pressure is also getting greater

However, as the saying goes, people are stress-free and floating, pressure is not necessarily a bad thing, and appropriate pressure can become the driving force for us to move forward, towards one peak

Recently, a research team led by Fabio Cominelli, a professor in the Department of Medicine and Pathology at Case Western Reserve University, published a report in the Proceedings of the National Academy of Sciences (PNAS) titled: Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through Research paper on IL-23/IL-22 signaling

The study showed that chronic stress has a protective effect

Inflammatory bowel disease (IBD) is a chronic, nonspecific inflammatory disease of the intestine whose cause is not yet well understood, including ulcerative colitis (UC) and Crohn's disease (CD).

Although scientists have gained a better understanding of this intestinal disease in recent years, its definite pathogenesis remains elusive

Currently, psychological stress has been identified as an important risk factor

TLO is formed after birth with dense CD4+ T cells, follicular dendritic cells, and B cell populations that are immune cells

In this study, the research team looked at a mouse model (SAMP) of Crohn's disease (CD)

In addition, stress did not significantly increase inflammation of the small or large intestine in SAMP mice, nor did it alter the composition

Because of the inherent flaws in the method of measuring the microbiome, the research team subsequently performed a fecal microbiome transplant

Subsequently, the team knocked out the IL-23 receptors

Notably, after inducing secondary colon injury with sodium glucose sulfate, colitis in stressed SAMP mice improved

Often, stress is associated

Professor Fabio Cominelli, the paper's corresponding author, said chronic stress that lasts for six weeks is beneficial for preventing "secondary injury" (secondary enteritis

Together, the study shows that chronic psychological stress induces colonic TLO formation through intrinsic alterations in IL-23 signaling, rather than through the influence of

Finally, Professor Fabio Cominelli said that whether we need stress or not depends entirely on the definition of stress, in fact, it is better
to use the word "stimulus".
Because in life, it's good to have a little bit of stress, but to bear it
in the right way.

Original Source:

Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling.
PNAS， 2022.