PNAS: Professor Shao Zhimin's team draws a triple-negative breast cancer-specific transcript map to perfect the "Fudan tetratype"!

Breast cancer is the malignant tumor with the highest incidence in women, of which triple-negative breast cancer is the most "dangerous", accounting for about 15-20% of all breast cancers, and its risk of recurrence and metastasis is significantly higher than that of other breast cancer subtypes
.
Due to the lack of effective therapeutic targets, triple-negative breast cancer has poor long-term efficacy
.
Previously, in order to explore the potential targets of precision treatment of triple-negative breast cancer, the team of Professor Shao Zhimin and Professor Jiang Yizhou of the Cancer Hospital drew the largest genetic map of triple-negative breast cancer for the first time in the world, in addition, the research team carried out a series of clinical studies on the precision treatment of triple-negative breast cancer, and with the guidance of the precision treatment strategy of "Fudan classification", the efficacy of the previous "untreatable" triple-negative breast cancer was nearly tripled
.

RNA is an important "messenger" for cells to transmit genetic information, and once a cell becomes cancerous, it is likely to produce abnormal RNA, that is, "tumor-specific transcripts"
.
Recently, the team of Professor Shao Zhimin and Professor Jiang Yizhou of Fudan University Cancer Hospital and Professor Huang Shenglin's team discovered that there are a large number of "tumor-specific transcripts" in the cells of triple-negative breast cancer, and successfully mapped the world's first "tumor-specific transcript" of triple-negative breast cancer
.
The research results were published online on November 8 in the international authoritative journal Proceedings of the National Academy of
Sciences.