PNAS: Pig coronavirus can replicate in human cells.

Oct 16, 2020 /--- -- A new study from the University of North Carolina at Chapel Hill suggests that pig strains may also spread to humans.
first discovered in 2016, the coronavirus strain, known as SADS-CoV, originated from bats and infected pigs across China.
outbreak of the disease could cause serious economic damage in many countries.
(Photo Source: www.pixabay.com) has demonstrated the virus's potential threat to people in laboratory tests that show that SADS-CoV can replicate effectively in human liver, bowel cells, and channel cells.
findings were published on PNAS on October 12.
Although it belongs to the same family as SARS-CoV-2, the coronavirus B that causes the respiratory disease COVID-19 in humans, SADS-CoV is a coronavirus that causes gastrointestinal disease in pigs.
the virus can cause severe diarrhea and vomiting, especially in piglets.
SADS-COV is also different from the common cold coronavirus HCoV-229E and HCoV-NL63 in humans. Ralph Baric, author of the
article, said: "While many researchers are concerned about β coronavirus such as SARS and MERS, in practice, α coronavirus also has important implications for human health, given its potential for rapid transfer between species."
Though it is not known to date whether SADS-CoV will affect humans, the COVID-19 pandemic is an effective reminder that many of the coronavirus strains found in animals may also infect humans - an effect known as spillover effects.
the study, conducted by Baric Labs in collaboration with UnC-Chapel Hill research specialist and master's degree in public health, suggests that humans may be susceptible to SADS-CoV spills.
Edwards, the study's first author, tested several types of cells by infecting cells with a synthetic strain of SADS-CoV to understand how high the risk of cross-species contamination is.
the study suggests that many mammalian cells, including the lungs and intestines of the original generation, are susceptible to infection.
, SADS-CoV, unlike SARS-CoV-2, which mainly infects lung cells, shows higher growth rates in intestinal cells in the human gut, according to Edwards.
cross-protective herd immunity usually prevents many coronavirus from being found in human-infected animals.
, however, tests conducted by Edwards et al. have shown that humans have not yet developed this immunity to SADS-CoV.
(bioon.com) Source: Swine coronavirus replicates in human cells Source: Caitlin E. Edwards, Boyd L. Yount, Rachel L. Graham, Sarah R. Leist, Yixuan J. Hou, Kenneth H. Dinnon, Amy C. Sims, Jessica Swanstrom, Kendra Gully, Trevor D. Scobey, Michelle R. Cooley, Caroline G. Currie, H. Randell, Ralph S. Baric. Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to india. Proceedings of the National Academy of Sciences, 2020; 202001046 DOI: 10.1073/pnas.2001046117.