PNAS: Obesity hormones increase the risk of sepsis.

, June 24, 2020 /PRNewswire/ --- Scientists from the Gulbenkian de Ci?ncia Institute (IGC), led by Lu?s Moita, have found that a hormone believed to treat obesity reduces the body's resistance to bacterial infections and increases the risk of sepsisThe findings were recently published in PNASsepsis is a potentially fatal disease caused by an organism's disorderof response to infection, leading to organ failureA recent study published in the scientific journal The Lancet estimated that sepsis infected 49 million people in 2017 and killed 11 million worldwideTo expand understanding of the disease, the IGC's Luis Moita team studied whether a hormone called GDF15 (growth and differentiation factor 15) could play a role in sepsisThis hormone has been widely studied in many laboratories and drugs as a potential drug for the treatment of obesity(Photo:IGC researchers measured the levels of GDF15 in blood samples of sepsis patients treated in intensive care units and compared them to healthy individuals and patients diagnosed with appendicitisThe results showed that gDF15 levels in patients with sepsis increased compared to other groups, and high levels of hormones were associated with mortalitystudy was conducted in mice that were missing the GDF15 geneThe results showed that mice survived better in bacterial abdominal infections similar to sepsis in human patients, suggesting that the hormone played a role in sepsisThe researchers then looked at what caused the survival rate of mice without GDF15 to improveThey point out that these mice were able to absorb large amounts of white blood cells in the abdomen, especially neutrophils, to better control infection and prevent it from spreading rapidly to other parts of the body"At a time when many pharmaceutical companies and groups are considering using GDF15 as a complementary treatment for obesity, it is important to remember that this treatment strategy may increase the risk of serious infections, including sepsis," warnsLu?s Moita"(Bio Valley Bioon.com)source:-In-man in-man-obesity man sansisoriginal source:Santos, I, et al(2020)CXCL5-mediated recruitment of neutrophils into the peritoneal of the gdf15-de-si PNASdoi.org/10.1073/pnas.1918508117.
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