PNAS: Chinese Academy of Sciences scholars reveal the regulatory mechanism of breast cancer-related macrophages

On January 31, 2022, the international academic journal PNAS published online the latest research results of Hu Guohong's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, entitled "miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression", which clarified Novel regulatory mechanism and targeted therapy strategy of tumor-associated macrophages in breast cancer
.

Globally, breast cancer is the most common malignant tumor in women and one of the most lethal types of malignant tumors
.

Graduate students Ma Chengxin, He Dasa, Tian Pu, etc.
, under the guidance of researcher Hu Guohong, found that breast cancer cells induce the high expression of miR-182 in macrophages through the TGFβ signaling pathway, and miR-182 directly inhibits the expression of the downstream TLR4 gene to cause macrophages.
The inactivation of the NFκb signaling pathway in cells in turn causes the polarization of macrophages to the pro-tumor M2 phenotype, which ultimately promotes the occurrence and development of breast cancer
.

In conclusion, this study revealed the important role of the TGFβ/miR-182/TLR4 signaling axis on tumor-associated macrophage polarization, and provided a rationale and strategy for RNA-based macrophage-targeted therapy
.

Researcher Hu Guohong from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences is the corresponding author of the paper, and doctoral student Ma Chengxin is the first author
.

Article link: https:// note: The functional mechanism and targeting strategy of miR-182 in regulating abnormal polarization of tumor-associated macrophages