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T cells patrol the body in search of cancer and pathogens
The scientists used gene editing to turn off the production of KRT19 or TGM2 in mouse pancreatic tumors
Why does this layer of protein repel T cells in the tumor? "It's a bit counterintuitive because CXCL12 is a chemokine (chemoattractant) that attracts immune cells," Wang said
The study was published in the Proceedings of the National Academies of Sciences
Journal Reference :
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F.