PNAS: Blocking a protein can inhibit liver and bile duct cancer.

Introduction: liver cancer is one of the most common digestive tract cancers in China. About 110000 people die of liver cancer every year in China, accounting for 45% of the world's liver cancer deaths.cholangiocarcinoma is a malignant tumor occurring in the biliary system, and is a relatively common malignant tumor disease. The incidence rate ofis high and it is difficult to treat these two diseases.recently, Spanish scientists have discovered a protein that can inhibit the development of liver cancer and cholangiocarcinoma.researchers have found a mechanism to control the development of liver cancer.the study was published in the Journal of the National Academy of Sciences (PNAs).partly funded by the Spanish anti cancer association.this study found a protein that, when blocked, significantly reduces the impact and progression of cholangiocarcinoma.this work is possible because researchers from the computer network information center (CNIC) of the Chinese Academy of sciences have developed an animal model, and changes in bile acid production have been shown to be responsible for this type of tumor.liver cancer is the fifth most common cancer in the world and the second leading cause of cancer-related death.cholangiocarcinoma is the second most common type of liver cancer, which begins in the bile duct and develops asymptotically clinically.due to the absence of early markers, most patients were diagnosed as advanced and died of cancer spread or metastasis.in this study, led by Guadalupe Sabio, Alfonso Mora and Roger J. Davis, mice with liver free JNK1 and jnk2 proteins were bred.Dr. Sabio explained, "when we eat too much, these proteins are activated and, to a certain extent, cause the liver to store too much fat (i.e., fatty liver or steatosis).and lead to insulin resistance, so these proteins are very important for the study of obesity and diabetes."the researchers also found that these two proteins control the production of bile acids in the liver, which are essential for the proper digestion of fat and the absorption of fat soluble vitamins (a, D, e and K).the lack of JNK1 and jnk2 in the liver leads to changes in the enzymes responsible for cholesterol and bile acid metabolism, and in the mice analyzed, excessive bile acids in the blood were observed.lack of JNK in the liver alters the production of bile acids and causes cholestasis. The researchers explained that the accumulation of bile acids has a "toxic effect" on the liver over time.the bile duct began to overproliferate, triggering the formation of a variety of cholangiocarcinoma. The clinical markers are very similar to those of patients with this type of cancer.in fact, this is the first time that they have found an increase in the biomarkers of patients with cholangiocarcinoma in a mouse model.this suggests that these mice may provide new clues for the evaluation of new therapeutic methods for cholangiocarcinoma.JNK the lack of JNK is the first mock exam for cholangiocarcinoma. This model has led CNIC researchers to collaborate with University of Massachusetts J Roger Davies laboratory to find a protein that plays a key role in tumorigenesis.the protein regulates the metabolism of bile acid and liver fat.PPAR deficiency reduces liver cancer caused by JNK deficiency. Although it is not known whether these data can be inferred from human patients, in fact, the existence of the first animal model will allow the study of a tumor that is still only diagnosed at a later stage when metastasis has occurred.early studies have shown that JNK blockade can prevent the development of hepatic steatosis.this is why various clinical trials have been launched for these protein inhibitors.the researchers believe these new findings are a wake-up call for these drugs.although the work has been tested only in mice, the researchers point out that we must be careful about the results of the liver in patients treated with these new drugs.reference: [1] [2] recommended reading: fighting the epidemic situation, transforming medical network content team series report: [breakthrough] scientists of the three countries jointly developed a new "detoxification version" of erythromycin, which greatly reduced the side effects! [PNAs] Yale University Research! The switch to control the inflammation caused by overeating has been found! [new findings] black raspberries, or a new "Star" in reducing skin inflammation, can damage arteries and increase the risk of heart disease, according to Ohio State University research