PNAS: Activate a protein, and the efficacy of cancer drug treatment is greatly enhanced!

Colorectal cancer is a malignant tumor that is extremely harmful to the human body
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Colorectal cancer, commonly known as "colorectal cancer", usually refers to colorectal cancer, which is a general term for cancers that occur in the rectum and colon
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The specific cause is not yet entirely clear, may be related to genetics, genetic, life>
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Bowel cancer is the fourth most common cancer in the UK, and more than 42,000 people are diagnosed with bowel cancer each year
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Recently, scientists at the University of Birmingham conducted in-depth research on this cancer
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As people’s work pressure increases and their daily diets become more and more irregular, many diseases have emerged
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• The hazards of increased intestinal secretions: colorectal cancer will appear mainly because of the irritation of the intestinal mucosa
  .

  
  A small amount of mucus secretions can be discharged with the stool to make the surface of the stool organized
  
  

• The risk of tumor ulceration
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  The harm of tumor ulcers is very serious
  
  

• The danger of being late
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  Due to its continuous expansion, advanced colorectal cancer can invade surrounding tissues and organs, causing dysuria, frequent urination, and painful urination
  
  

• Danger of bowel obstruction
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  Colorectal cancer can cause incomplete or complete low intestinal obstruction symptoms, which can cause abdominal distension, abdominal pain, or constipation or constipation symptoms
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  During the examination, the abdominal bulge, intestinal shape, and local tenderness can be seen.
  At the same time, strong bowel sounds can be heard
  .
  

• Being late can affect bowel movements
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  Patients with advanced colorectal cancer may experience local irritation of cancer such as increased frequency of defecation, incomplete defecation, frequent defecation, and falling
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  In addition, the enlargement of the tumor can also cause intestinal stenosis, which eventually leads to intestinal obstruction
  .
  The patient caused more suffering
  .
  

Scientists at the University of Birmingham have discovered a way for the first time in their new study to prevent certain drugs from acting on bowel cancer patients
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This result has never been found in other studies before
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This discovery will be of great significance
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It will not only promote the scientific community and clinicians' understanding of bowel cancer, but also develop more effective treatments
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It provides ideas and inspiration for the treatment of colorectal cancer, so that they can bring the gospel to more colorectal cancer patients
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They published the results of this study in the journal PNAS
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In the research led by this group of scientists, they collected 184 bowel cancer patients to participate in the COIN trial, and conducted detailed analysis and research on their tumor samples and medical records; at the same time, they also conducted mouse research and cell culture environment research.
And precancerous colorectal cancer laboratory model research
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Andrew Bergs, Professor of Cancer Genetics and Surgery at the University of Birmingham, explained: “About 60% of bowel cancers are very sensitive to a drug called an anti-egfr inhibitor
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It has a therapeutic effect on cancer patients
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However, in spite of this, in Among cancers that are sensitive to these drugs, these drugs are only effective for nearly half of the patients
.
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