PNAs: a new type of inflammation inhibitor can prevent fetal neurodevelopmental disorders

March 21, 2019 / BIOON / - a new study published in PNAS shows that an enzyme inhibitor developed by Professor Bruce hammock of the University of California, Davis, UCD and his colleagues can reduce inflammation in the brain of mice born in mothers with immune system activation The inflammation caused by this soluble epoxide hydrolase is associated with neurodevelopmental disorders in these mice Source: PNAs "inhibiting the activity of this enzyme prevents inflammation in the brains of these mice and symptoms like autism and schizophrenia." Professor Kenji Hashimoto, co-author of the study and a member of the forensic mental health center at Chiba University in Japan, said The inflammatory signals produced by bacterial infection of pregnant mothers can cause the fetus to suffer from symptoms similar to autism and schizophrenia These diseases also have a genetic trend By inhibiting soluble epoxide hydrolase, the researchers reversed cognitive and social impairments in mice babies This may be due to an increase in the amount of natural substances in the brain that prevent inflammation in the brain "There is increasing evidence that inappropriate maternal immune responses to infection during pregnancy increase the risk of fetal autism spectrum disorders." Dr Isaac pessah, associate dean of research and graduate education and senior professor of molecular biology at UCD veterinary college, said he was not involved in the study This study shows that the inhibition of soluble epoxide hydrolase can prevent some symptoms in mouse models, which has not been found in the past Reference: Bruce hammock et al Key role of double epoxy hydrogen in the neurodegenerative disorders of offspring after material activation, procedures of the National Academy of Sciences (2019) Doi: 10.1073/pnas.1819234116