PLoS Med: The longer an individual is obese, the higher the risk of cardiovascular metabolic disease

December 14, 2020 // -- A recent study published in the international journal PLoS Medicine entitled "Duration of obesity between ages 10 and 40 years and its relationship with cardiometabolic disease risk factors: A cohort study" found that scientists from institutions such as Loughborough University found that longer body obesity durations or lower levels of all cardiovascular metabolic disease factors were directly related.
Photo Source: CC0 Public Domain researchers say obese people may not all have the same risk of cardiovascular metabolic risk factors, and scientists speculate that the length of time a person is obese in their lifetime may influence this difference, using three Data from the British Birth Cohort Study, which collected body mass index information from 20,746 participants aged 10-40 and cardiovascular metabolic risk factors including blood pressure, cholesterol and hemoglobin glycation, were analysed.
The longer the body is obese, the worse the number of cardiovascular metabolic risk factors it measures, and the association of glycation hemoglobin (HbAc1) is particularly strong, compared to people who are not perennially obese, individuals who have been obese for less than five years HbAc1 levels increased by 5%, while in individuals who were not obese for 20-30 years, HbAc1 levels increased by 20% (95% CI 17-23).
, this increased risk persists when the severity of obesity in the course of life is adjusted.
other measures of cardiovascular metabolic disease risk (systolic and espressolic, HDL cholesterol) are also associated with the duration of individual obesity, although these factors are largely reduced when adjusting for the severity of obesity.
the results suggest that health policy recommendations aimed at preventing early obesity and reducing lifetime exposure may help reduce the risk of obesity in the population, which is not related to the severity of obesity in the population, the researchers said.
() Original source: Norris T, Cole TJ, Bann D, Hamer M, Hardy R, Li L, et al. (2020) Duration of obesity exposure between ages 10 and 40 years and its relationship with cardiometabolic disease risk factors: A cohort study. PLoS Med 17(12): e1003387. doi:10.1371/journal.pmed.1003387。