 Home > Biochemistry News > Biotechnology News > Plos Biology: The regulatory mechanism that inhibits cholesterol synthase and accelerates the growth of renal cell carcinoma

Plos Biology: The regulatory mechanism that inhibits cholesterol synthase and accelerates the growth of renal cell carcinoma

 Last Update: 2021-08-11
 Source: Internet
 Author: User

Tags

shenzhen technology co ltd

cell

article published

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

It is generally believed that high serum cholesterol will cause tumor deterioration and complications in cancer patients, and affect the prognosis of cancer patients, while low serum cholesterol is beneficial to the recovery of cancer patients

Recently, the research of the Mi Shengli research group of Shenzhen International Graduate School proved that although the inhibition of cholesterol synthesis rate-limiting enzyme HMGCR in renal cancer cells leads to a decrease in serum cholesterol in tumor-bearing mouse models, glycolysis in RCC tumor tissues is enhanced and lactic acid accumulates.

3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the main rate-limiting enzyme in the cholesterol synthesis pathway.

This study proved that the degree of inhibition of HMGCR is positively correlated with tumor glycolysis and RCC growth

Related results were recently published in "Public Science Library Biology" under the title "HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma" (HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma) (Plos Biology) on

Paper link:

https://journals.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

L-Ascorbate-2-Monophosphate Feed Grade

CAS No.: 109620-90-8

Feed Grade

Potassium Sorbate from reliable manufacturer

CAS No.: 590-00-1

Food Grade

Doxycycline Hydrochloride

CAS No.: 10592-13-9

Pharmaceutical Grade

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.