Plos Biol: First Data Support: Fragmentation sleep is dangerous! Can cause chronic inflammation and arteriosclerosis

It's certainly pleasant to wake up to a natural wake, but many people in the modern world have sleep disordersAccording to the WHO survey, about one-third of people worldwide have sleep disorders, and 38.2 percent of people in our country have various types of sleep disorders, and it can be said that one in three people has sleep problemsA recent study by researchers at the University of California, Berkeley, has revealed for the first time the association between fragmented sleep and chronic inflammation and arteriosclerosisnight-time sleep interruptions and blocked arteries tend to creep up as we get olderWhile the two diseases may seem irrelevant, a new study by the University of California, Berkeley, helps explain why they are actually pathologically intertwinedsleep scientists at the University of California, Berkeley, have revealed that night-time fragmentation can lead to the formation of fatty arterial plaques, or atherosclerosis, which can lead to fatal heart disease"We found a unique link between fragmented sleep and chronic circulatory inflammation through the blood stream, which in turn is associated with a large number of coronary artery plaques," said Matthew Walker, a senior author of thestudy and a professor of psychology and neuroscience at the University of California, Berkeley"。study, published June 4 in the journal PLOS Biology, found that lack of sleep is a key risk factor forcardiovasculardisease, and that cardiovascular disease is the number one killer in the United States, killing about 12,000 people a week, compared with an average of 1,000 deaths a day during the U.SCOVID-19pandemic, which is close to the death toll from cardiovascular disease"For the first time
, as far as we know, these data link fragmented sleep, inflammation and atherosclerosis in humans," said Raphael Vallat, a postdoctoral researcher at the Walker Center for Human Sleep Sciences at the University of California, Berkeley, and lead author of the study Risk factors known humancardiovascular disease include poor diet, lack of exercise, obesity, high blood pressure, and smoking Using statistical modeling, the researchers analyzed diagnosis data from more than 1,600 middle-aged and elderly people using a national data set called the Multi-ethnic Study of Atherosclerosis To isolate the effects of sleep quality on heart health, the study controlled high-risk behaviors such as age, race, gender, body mass index, sleep disorders, blood pressure, and smoking Participant characteristics by atherosclerosis severity (CAC category) the researchers then followed the results of the study participants, analyzing their blood tests, their calcium scores (measuring plaque aggregation), and several different sleep indicators, including a week's watch to assess sleep, and brain wave signals measured in a sleep lab overnight The end results clearly show that sleep pattern disorders are associated with high concentrations of circulating inflammatory factors, especially white blood cells (mononucleoblasts and neutrophils), which are key factors leading to atherosclerosis in revealing this link to chronic inflammation, the results suggest that a missing intermediate factor (chronic inflammation) is contributing to a causal relationship between sleep fragments and hardening of blood vessels "In fact, these correlations in humans reflect recent data that experimentally manipulated mice sleep disruption seiscause elevated levels of circulatory inflammation, leading to atherosclerosis in rodents," Varat added "
the graph reveals a significant correlation between fragmented sleep and an increase in absolute neutrophil count, thus predicting higher CAC scores The link between fragmented sleep and atherosclerosis is determined to some extent by the effects of elevated neutrophils researchers say the findings, which link poor sleep to atherosclerosis through chronic inflammation, are important for public health For example, atherosclerosis usually begins in early adulthood Unfortunately, this process goes unnoticed to a large extent, and when plaque builds up in straight middle age, it suddenly prevents arterial blood flow to the heart, lungs, brain or other organs, and is therefore known as the "silent killer." "The hidden nature of this disease requires us to pay attention to our own hygiene, even before we enter middle age," said Vyoma Shah, a doctoral student at the Walker Laboratory in and co-author of the study "。 "To more accurately measure a person's sleep quality, a clinical-grade sleep tracker is recommended because research has found that subjective assessments of one's own sleep are not reliable," said Shah If you track your sleep patterns in an objective way, just as you track your weight, blood pressure, or cholesterol , you may change your sleep habits, which can have a noticeable impact on your future health "As chronic inflammation becomes a bridge between poor sleep and cardiovascular disease, it is necessary to explore its role in many other diseases," said Walker The link between fragmented sleep and chronic inflammation may not be limited to heart disease, but may also include mental health and neurological disorders such as depression and Alzheimer's disease Tips improve the quality of sleep
sleep regularly and go to bed and get up on time every day as part of a nightly relaxation, stay away from computers, smartphones and TV screens for the last hour of bedtime, and keep your phone and other digital devices outside the bedroom do some physical exercise during the day soaked up in the sun in the morning avoid ingress such as caffeine and sedatives such as alcohol at night If you can't sleep, get up and do some relaxing activities outside the bedroom, such as reading in the dim light Go to bed again when you're sleepy If you know that your snoring is severe or you are very tired during the day, check for sleep apnea If you are experiencing insomnia, consult your doctor and ask for cognitive behavioral therapy for insomnia (CBTI)