Physiological function of resveratrol

2013-01-11 classification: efficacy effect: 0 people comment on the protection of cardiovascular and hypolipidemic effects: epidemiological studies show that moderate drinking of wine is conducive to cardiovascular health, and previous views believe that ethanol plays a role, but with the deepening of the study More and more scholars think Resveratrol in wine is the main functional factor of cardiovascular protection Resveratrol's effect on cardiovascular system is mainly manifested in its effect on lipid metabolism and platelet aggregation, so as to play the role of antithrombotic, anti atherosclerotic and coronary heart disease, anti ischemic heart disease and anti hyperlipidemia Resveratrol can significantly reduce the content of serum cholesterol and triglyceride It has the effect of lowering blood lipid The animal experiments showed that resveratrol could reduce the accumulation of peroxides in rat liver, the levels of AST and alt, LPO and FFA in serum It can prevent the formation of peroxides induced by ADP and NADPH in rat liver, inhibit the increase of TG and LPL, and reduce the formation of 14C palmitic acid fat in rat liver Liver protection and antioxidation: resveratrol can protect the liver and inhibit the accumulation of lipid peroxides in the liver The protective effect of resveratrol glycoside on primary cultured rat hepatocytes injured by CC1 was studied by Huang Zhaosheng et al It was found that resveratrol glycoside could effectively protect the injured hepatocytes The cell survival rate was significantly increased in the range of 1 × 10-1 × 10-4mmol / L, and 88.7% in the range of 1 × 10-5mmol / L, which was close to the level of normal cultured hepatocytes Resveratrol glycoside can reduce the increase of no and MDA, inhibit the activity of NOS, increase the activity of SOD and fgsp Px, reduce the consumption of GSH, and protect hepatocytes Resveratrol has a strong inhibitory effect on lipid peroxidation induced by free radical system It can significantly reduce the content of malondialdehyde in tissues, improve the activity of SOD, cat and gah-px, and has a protective effect on cerebral ischemia and tissue damage Resveratrol also has the functions of antioxidation, inducing free radicals and affecting arachidonic acid metabolism Resveratrol has the most remarkable pharmacological effect, because these physiological metabolism involves many physiological diseases closely related to human health, such as atherosclerosis, Alzheimer's disease, senile degenerative disease, viral hepatitis, inflammation and allergic reaction, gastric ulcer, radiation damage, etc., which are not only related to people's health, but also related to people's quality of life Antitumor and estrogen like effects: resveratrol can inhibit the growth of cancer cells The research results on the antitumor mechanism of resveratrol reveal that resveratrol has antitumor effects in three stages of tumor initiation, promotion and development By inhibiting cytochrome enzyme, inducing detoxification enzyme, inhibiting cyclooxygenase, inhibiting protein kinase, antagonizing estrogen, changing autocrine growth regulator, inducing tumor cell differentiation and promoting cell apoptosis, the growth of cancer cells can be inhibited Resveratrol is a kind of estrogen derived from plants It has an obvious preventive effect on hormone dependent tumors (including breast cancer, prostate cancer, endometrial cancer and ovarian cancer) It can also make up for the lack of estrogen secretion in postmenopausal women, so as to reduce the risk of osteoporosis